keratoacanthoma/fever

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Brain Abscess and Keratoacanthoma Suggestive of Hyper IgE Syndrome.

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Hyper immunoglobulin-E (IgE) syndrome is an autosomal immune deficiency disease. It is characterized by an increase in IgE and eosinophil count with both T-cell and B-cell malfunction. Here, we report an 8-year-old boy whose disease started with an unusual skin manifestation. When 6 months old he

[Vemurafenib-induced toxic epidermal necrolysis].

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BACKGROUND Herein we report the first case of toxic epidermal necrolysis (TEN) occurring with use of vemurafenib. METHODS A 75-year-old female patient was being treated with vemurafenib for stage IV melanoma with BRAF V600E mutation. She suddenly presented fever, diffuse pruriginous maculopapular

[Dabrafenib (Tafinlar) therapy - effect and side effects].

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Despite the continuously increasing incidence of melanoma, over decades the therapy has barely changed. However, since 2011 the "still water" moves, now with multiple medications the patient survival can be improved. Dabrafenib is the second registered BRAF kinase inhibitor. In clinical trials it

Economic Burden of Toxicities Associated with Treating Metastatic Melanoma in the United States.

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BACKGROUND Little has been reported on the costs of managing the adverse events (AEs) associated with current therapies for patients with regional or distant metastatic melanoma. OBJECTIVE To identify treatment-related AEs in patients with metastatic melanoma and to estimate the associated costs of

Human Orf: An Under-recognized Entity.

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Dear Editor, Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats,

Phase I study of vemurafenib in children with recurrent or progressive BRAF ^V600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002)

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Background: BRAF^V600E mutation is present in a subset of pediatric brain tumors. Vemurafenib is an oral, selective ATP-competitive inhibitor of BRAF^V600E kinase. The goal of this multi-center study conducted through the Pacific Pediatric Neuro-Oncology Consortium (PNOC)

Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial.

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BACKGROUND Brain metastases are common in patients with metastatic melanoma and median overall survival from their diagnosis is typically 17-22 weeks. We assessed dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain. METHODS We undertook a multicentre,

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keratoacanthoma/fever

Brain Abscess and Keratoacanthoma Suggestive of Hyper IgE Syndrome.

[Vemurafenib-induced toxic epidermal necrolysis].

[Dabrafenib (Tafinlar) therapy - effect and side effects].

Economic Burden of Toxicities Associated with Treating Metastatic Melanoma in the United States.

Human Orf: An Under-recognized Entity.

Phase I study of vemurafenib in children with recurrent or progressive BRAF V600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002)

Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial.

The most complete medicinal herbs database backed by science

Phase I study of vemurafenib in children with recurrent or progressive BRAF ^V600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002)