kernicterus/glutathione

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Selective vulnerability of rat brain regions to unconjugated bilirubin.

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Hippocampus is one of the brain regions most vulnerable to unconjugated bilirubin (UCB) encephalopathy, although cerebellum also shows selective yellow staining in kernicterus. We previously demonstrated that UCB induces oxidative stress in cortical neurons, disruption of neuronal network dynamics,

Prevalence of glucose-6-phosphate dehydrogenase deficiency in jaundiced Egyptian neonates.

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BACKGROUND The enzyme, Glucose-6-phosphate dehydrogenase (G6PD), deficiency leads to impaired production of reduced glutathione and predisposes the red cells to be damaged by oxidative metabolites, causing hemolysis. Deficient neonates may manifest clinically as hyperbilirubinemia or even

Evaluation of oxidant and antioxidant status in term neonates: a plausible protective role of bilirubin.

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In vitro studies have shown unequivocally that bilirubin is an antioxidant. We hypothesized that bilirubin serves a physiological role of an antioxidant in vivo. To investigate the probable protective role of bilirubin in vivo, term babies with clinical jaundice were grouped into four

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