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kernicterus/seizures

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Spectrum and immediate outcome of seizures in neonates.

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OBJECTIVE To determine the frequency, etiology, the clinical types, and outcome of seizures in neonates during the course of stay in the neonatal unit. METHODS Cross-sectional study. METHODS Pediatric Department, LMCH, from February 2000 to April 2001. METHODS All neonates (1-28 days) presented with

Seizures etiology in the newborn period.

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OBJECTIVE To determine the causes of seizures in the newborn period. METHODS Cross-sectional analytical study. METHODS Neonatal Unit, Paediatric Department, Allied Hospital, Faisalabad, from April 2003 to June 2004. METHODS A total of 200 neonates of either gender who presented with seizures or

Risk factors associated with kernicterus in the newborn infant: importance of benzyl alcohol exposure.

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The prevalence of kernicterus in our neonatal intensive care unit (NICU) decreased from more than 2/1000 live births in 1980 to none in 1984. To clarify predictors of kernicterus, we examined the medical records of infants born during that time who died between 2 and 28 days of age. Infants were

A study of phenobarbital and dilantin in neonatal seizures.

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A total of 40 cases of neonatal convulsions of different nonmetabolic aetiological factors were studied. Patients with kernicterus were included in the study. Peak plasma phenobarbital concentrations after incremental loading doses of phenobarbital i.e. 10 mg/kg, 15 mg/kg, and 20 mg/kg were

Aetiology and types of neonatal seizures presenting at Ayub Teaching Hospital Abbottabad.

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BACKGROUND Neonatal seizures (NS) affect approximately 1% of neonates. Clonic, tonic, myoclonic and subtle seizures are the common types. Birth asphyxia, sepsis, metabolic derangements, intracranial bleed, kernicterus, tetanus and 5th day fits are the common aetiologies. This study was planned to

Lack of predictive indices in kernicterus: a comparison of clinical and pathologic factors in infants with or without kernicterus.

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A review of 398 neonatal autopsies at Downstate Medical Center revealed 27 cases of kernicterus during the seven-year period from 1971 through 1977. With the current intensive care of the sick newborn, kernicterus continues to occur, mainly in premature infants with relatively low levels of serum

Kernicterus in a neonatal foal.

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A 5-day-old Thoroughbred foal was submitted to the necropsy service at the University of Kentucky Livestock Disease Diagnostic Center. The foal had a clinical history of seizure activity and severe icterus. A complete blood count and serum chemistry analysis indicated that the foal was anemic

Bilirubin adsorption therapy and subsequent liver transplantation cured severe bilirubin encephalopathy in a long-term survival patient with Crigler-Najjar disease type I.

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Crigler-Najjar disease (CN) type I is characterized by persistent unconjugated hyperbilirubinemia from birth. The male patient here was diagnosed with this disease as a neonate and had been treated by phototherapy. At age 16 he suddenly developed generalized convulsions, followed by impaired

New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters.

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BACKGROUND Kernicterus is an irreversible brain damage caused by bilirubin deposition in selective brain regions. Sick and preterm infants with hyperbilirubinemia are particularly susceptible to the condition. METHODS We studied autopsied brain tissue from a premature female infant with kernicterus

Neurological disorders in children and adolescents.

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OBJECTIVE To ascertain the prevalence of active epilepsy, febrile seizures (FS), cerebral palsy (CP) and tic disorders (TD) in aged 19 years or less. METHODS This was a cross-sectional observational study conducted as a two-stage door-to-door survey of a stratified randomly selected population in

Neonatal jaundice in Saudi newborns with G6PD Aures.

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Sixty-five of 3261 (2%) Saudi neonates were found to be severely G6PD-deficient during a cord blood screening programme conducted from April to December, 1992. However, at the time of molecular studies, the blood samples were available from only 20 randomly selected children, aged from 1 to 6 years.

The etiology of severe neonatal hyperbilirubinemia and complications of exchange transfusion.

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Exchange transfusion (ECT) has an important role in preventing kernicterus in the treatment of indirect hyperbilirubinemia of the newborn. In present study, the etiology of hyperbilirubinemia and complications of ECT were studied over a five-year period in the Eastern Mediterranean region of Turkey.

[Neurological pathology in the newborn infant].

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The purpose of this work was to review the literature about the newborn neurological pathology and to compare it with our results starting from the observation of 650 children who born at the Clinical Hospital of Porto Alegre from September 1979 to June 1980. Out of these, 100 presented with

Risk factors and clinical profiles in Turkish children with cerebral palsy: analysis of 625 cases.

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The aim of the study was to investigate risk factors, clinical profiles and gross motor function levels of Turkish children with cerebral palsy (CP). A total of 625 consecutive children with CP, who were rehabilitated in the pediatrics rehabilitation clinic between 2000 and 2004 years, were

Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia.

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Bilirubin-induced neurologic dysfunction (BIND) and kernicterus has been used to describe moderate to severe neurologic dysfunction observed in children exposed to excessive levels of total serum bilirubin (TSB) during the neonatal period. Here we use a new mouse model that targets deletion of the
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