An evaluation has been made of the action of khellin, a furochromone derivative from Ammi visnaga, at the dose of 50 mg q.i.d. during four weeks, on the plasma lipids of 20 non-obese normolipaemic male subjects after a placebo period of two weeks. The plasma lipids were measured each week and one
Timefurone and khellin (10 mg/kg/day, gavage, 14 days) significantly lowered low density lipoprotein cholesterol, high density lipoprotein cholesterol, and total cholesterol. Khellin-induced changes were significantly greater than those induced by timefurone. Neither drug altered body weights or
Khellin and khelloside (khellol glucoside) were examined in female cynomolgus monkeys to substantiate their ability to favorably modify serum lipoprotein cholesterol. Clinical chemistry parameters were also measured to obtain information indicative of possible drug toxicity. Both drugs were
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