licochalcone a/hypoxia

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Licochalcone A Inhibits BDNF and TrkB Gene Expression and Hypoxic Growth of Human Tumor Cell Lines.

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Hypoxic cellular proliferation is a common feature of tumor cells and is associated with tumor progression. Therefore, the inhibition of hypoxic cellular proliferation is expected to regulate malignancy processes. Licochalcone A (LicA) is known to show inhibitory effects on cell growth in normoxia,

Special licorice extracts containing lowered glycyrrhizin and enhanced licochalcone A prevented Helicobacter pylori-initiated, salt diet-promoted gastric tumorigenesis.

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OBJECTIVE In spite of cytoprotective and anti-inflammatory actions, conventional licorice extracts (c-lico) were limitedly used due to serious side effects of glycyrrhizin. As our group had successfully isolated special licorice extracts (s-lico) lowering troublesome glycyrrhizin, but increasing

Protective effects of Wen-Pi-Tang against cultured renal epithelial cellular injury.

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A study was conducted to clarify whether extracts of Wen-Pi-Tang and its component crude drugs ameliorate renal cellular injury by assaying lactate dehydrogenase and malondialdehyde leakage from LLC-PK(1) cells in culture. The cells were cultured with various concentrations of the samples under two

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