linamarase/glioblastoma

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Cyanide bystander effect of the linamarase/linamarin killer-suicide gene therapy system.

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BACKGROUND The killer-suicide system linamarase/linamarin (lis/lin) uses the plant gene linamarase (beta-glucosidase) to convert the cyanogenic glucoside substrate, linamarin, into glucose and cyanide. We have studied the bystander effect associated with this new system mediated by the production of

Toxicity and delivery methods for the linamarase/linamarin/glucose oxidase system, when used against human glioma tumors implanted in the brain of nude rats.

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Glioblastoma multiforme (GBM) is one of the deadliest forms of cancer, with an average survival time of approximately 1year despite aggressive surgery, radiotherapy and chemotherapy. Here, we report a preclinical study by which the two main energy pathways of the tumor cells, oxidative

[The canine model in the gene therapy of glioblastoma].

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The group of research directed by Marta Izquierdo (in which I colaborate close to Dra. García-Escudero and other colleagues) has used in the last three years the linamarase/linamarin system for treatment of brain tumors in the rat. This is a killer/suicide method based upon the plant linamarase

Autophagy induction as an efficient strategy to eradicate tumors.

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The understanding of the mechanisms of cell-death execution and the role that they play in different diseases opens new therapeutic strategies. Currently, increasing evidence indicates that autophagy is a frequent cell-death mechanism, so the question arises: Could autophagy stimulation be

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