lychnophora staavioides/leukemia

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Production of an antiproliferative furanoheliangolide by Lychnophora ericoides cell culture.

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This work reports for the first time the production a furanoheliangolide (goyazensolide) by plant cell culture. Monitoring of the goyazensolide metabolism revealed that the maximum production occurred during the lag phase of the Lychnophora ericoides callus culture. The antiproliferative activity of

Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the South American Lychnophora antillana.

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Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 micrograms/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based

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