melodinus/anticancer

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A novel monoterpenoid indole alkaloid with anticancer activity from Melodinus khasianus.

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A novel monoterpenoid indole alkaloid with unprecedented 6/5/6/4/6 fused rings, khasuanine A (1), was isolated from the roots of Melodinus khasianus. The structure was determined by extensive analysis of its HR-MS, 1D-, and 2D-NMR spectra. Khasuanine A markedly inhibited the proliferation of PC3

Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi.

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Melodinine V (1) with a vincanol-eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon

Corrigendum to "A novel monoterpenoid indole alkaloid with anticancer activity from Melodinus khasianus" [Bioorg. Med. Chem. Lett. 27 (2017) 893-896]

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Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair.

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Cytotoxic indole alkaloids from Melodinus suaveolens, which belongs to the toxic plant family Apocynaceae, demonstrated impressive antitumor activities in many tumor types, but less application in glioblastoma, which is the lethal brain tumor. In the present study, we reported the anti-glioblastoma

[Demethyltenuicausine, a new bisindole alkaloid from Melodinus hemsleyanus].

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Demethyltenuicausine (I), a new bisindole alkaloid, was isolated from Melodinus hemsleyanus and its structure was determined by spectral analysis and semisynthesis. This compound showed antitumor activities in pharmacologicat tests.

[Studies on alkaloids from Melodinus moraei].

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To study the alkaloids from Melodinus moraei,seven compounds were separated and purified by column chromatography over silica gel, reverse phase silica gel and preparative HPLC. Their chemical structures were elucidated by MS and spectral data (1H-NMR, 13C-NMR) as

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