The present invention relates to novel piperidine derivatives useful as inhibitors of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, EC 2.4.1.80), methods for their preparation and their use in medicine, specifically in
The present invention relates to a novel piperidine derivative useful as an inhibitor of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, EC 2.4.1.80), methods for its preparation and its use in medicine, specifically in
INTRODUCTION
Glucosylceramide is the condensation product of UDP-glucose and ceramide and its formation is catalysed by glucosylceramide synthase (GCS, EC 2.4.1.80).
The enzymes involved in ceramide biosynthesis are localized on the cytosolic leaflet of the endoplasmic reticulum. The biosynthesis
INTRODUCTION
Glucosylceramide is the condensation product of UDP-glucose and ceramide and its formation is catalysed by glucosylceramide synthase (GCS, EC 2.4.1.80).
The enzymes involved in ceramide biosynthesis are localized on the cytosolic leaflet of the endoplasmic reticulum. The biosynthesis
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