nauclea officinalis/analgesic

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In vivo anti-inflammatory and analgesic activities of strictosamide from Nauclea officinalis.

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BACKGROUND Strictosamide is the main representative constituent of Nauclea officinalis Pierre ex Pitard (Rubiaceae), which has been used for a long time in China to treat diseases related to infection and inflammation, but its pharmacological activities are not well studied. OBJECTIVE This work

Analgesic, anti-inflammatory and anti-arthritic properties of aqueous and methanolic stem bark extracts from Nauclea pobeguinii (Rubiacee) in rats.

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Background Nauclea pobeguinii is a plant species found in the centre region of Cameroon. The stem bark of this plant is traditionally used to ease pain and cure inflammation. Method This study was undertaken to evaluate the effects of doses 150 and 300 mg/kg of the aqueous and methanolic stem bark

Nauclea latifolia: biological activity and alkaloid phytochemistry of a West African tree.

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Covering up to 2016Nauclea latifolia (syn. Sarcocephalus latifolius, Rubiaceae), commonly called the African pincushion tree, is a plant widely used in folk medicine in different regions of Africa for treating a variety of illnesses, including malaria, epilepsy and pain. N. latifolia has not only

Antipyretic and antinociceptive effects of Nauclea latifolia root decoction and possible mechanisms of action.

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BACKGROUND Nauclea latifolia Smith (Rubiaceae) is a small tree found in tropical areas in Africa. It is used in traditional medicine to treat malaria, epilepsy, anxiety, pain, fever, etc. OBJECTIVE The aim of this study was to investigate the effects of Nauclea latifolia roots decoction on the

Tramadol--a true natural product?

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We have independently investigated the source of tramadol, a synthetic analgesic largely used for treating moderate to severe pain in humans, recently found in the roots of the Cameroonian medicinal plant, Nauclea latifolia. We found tramadol and its three major mammalian metabolites

A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol.

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Tramadol, previously only known as a synthetic analgesic, has now been found in the bark and wood of roots of the African medicinal tree Nauclea latifolia. At present, no direct evidence is available as to the biosynthetic pathway of its unusual skeleton. To provide guidance as to possible

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