neoclerodane/breast neoplasms

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Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A.

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The success rate for central nervous system (CNS) drug candidates in the clinic is relatively low compared to the industry average across other therapeutic areas. Penetration through the blood-brain barrier (BBB) to reach the therapeutic target is a major obstacle in development. The rapid CNS

Two new neoclerodane diterpenoids from Scutellaria barbata D. Don growing in Vietnam.

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Various chromatographic separations of the aerial parts of Scutellaria barbata afforded two new neoclerodane diterpenoids, scutebatas S and T (1 and 2), along with scutebata D (3). Their structures were elucidated by spectroscopic methods including high-resolution electrospray ionization mass

Cytotoxic neoclerodane diterpenoids from scutellaria barbata D. Don.

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A new neoclerodane diterpenoid, barbatin H (1) together with fifteen known analogues (2-16) were isolated from Scutellaria barbata D. Don. Their structures were determined on the basis of NMR and HRMS spectral analysis and comparison with the reported data. All of those compounds were comparatively

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