otosclerosis/phosphatase

Otosclerosis is a complex bone dystrophy of the human otic capsule leading to conductive and sensorineural hearing loss. Since otosclerosis may, at least in part, be considered as an autoimmune-inflammatory disease, disturbed balance of TNF-alpha and osteoprotegerin (OPG) expression has been

Ceruminous glands in otosclerosis. A histopathological and histochemical study.

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The ceruminous glands of the external auditory canal skin of 20 patients suffering from otosclerosis were examined histologically and histochemically. The histological changes included flattening of the lining cells and widening of the lumina of the glands. Histochemical alterations were in the form

Relation between renin-angiotensin-aldosterone system and otosclerosis: a genetic association and in vitro study.

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OBJECTIVE Angiotensin II (Ang II) may be implicated in the regulation of bone remodeling, and its activity is related to several gene polymorphisms including AGT M235T for plasmatic and tissular concentrations of angiotensinogen (AGT), ACE I/D for the angiotensin-converting enzyme activity, and

Signaling by way of type IB and II bone morphogenetic protein receptors regulates bone formation in otospongiosis.

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OBJECTIVE The main goal of this study was to perform an immunohistologic analysis of bone morphogenetic protein receptors (BMPR) in otospongiosis. BACKGROUND BMP-2, -4, and -7 play an essential role in bone formation and repair. They do so as well in otosclerosis. It has been shown that these BMPs

Bone resorption in experimental otosclerosis in rats.

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Localized bone resorption in the otic capsules of experimental rats was induced by immunization with type II collagen. The otospongiosis-like lesion showed enlarged vascular spaces that contained many fibroblasts and macrophages as well as occasional osteoclasts. A high level of acid phosphatase

Vitamin D deficiency and otosclerosis.

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A prospective study of 47 patients with otosclerosis was undertaken to investigate the possible etiologic role of vitamin D undernutrition. The population comprised 27 women and 20 men, with a mean age of 46.4 years (range 21 to 79). The disease was bilateral in 43 patients, and cochlear involvement

Immunohistochemical evidence of BMP-2, -4 and -7 activity in otospongiosis.

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CONCLUSIONS This study is the first to show that bone morphogenetic proteins (BMP)-2, -4 and -7 play a role in active phase otosclerotic bone remodelling (otospongiosis). OBJECTIVE The role of BMPs in various tissue growth and repair mechanisms is an ongoing topic in the literature. BMP-2, -4 and -7

Activated osteoclasts with CD51/61 expression in otosclerosis.

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OBJECTIVE Stapes ankylosis is supposed to be a disease with variable histopathology caused by otosclerosis or pseudo-otosclerosis. Persistent measles virus infection of the otic capsule could induce reactivation of quiescent embryonic osteoclasts in otosclerosis. BACKGROUND Presence of measles virus

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