phyla/immunostimulator

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Immunostimulatory CpG motifs in the genomes of gut bacteria and their role in human health and disease.

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Toll-like receptor (TLR) signalling plays an important role in epithelial and immune cells of the intestine. TLR9 recognizes unmethylated CpG motifs in bacterial DNA, and TLR9 signalling maintains the gut epithelial homeostasis. Here, we carried out a bioinformatic analysis of the frequency of CpG

Sensing Gram-negative bacteria: a phylogenetic perspective.

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Gram-negative bacteria represent a major group of pathogens that infect all eukaryotes from plants to mammals. Gram-negative microbe-associated molecular patterns include lipopolysaccharides and peptidoglycans, major immunostimulatory determinants across phyla. Recent advances have furthered our

CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved.

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Oligodinucleotides containing CpG motifs stimulate vertebrate immune cells in vitro, have proven efficacy in murine disease models and are currently being tested in human clinical trials as therapies for cancer, allergy, and infectious disease. As there are no known immunostimulatory motifs for

Distribution and Diversity of Glycocin Biosynthesis Gene Clusters Beyond Firmicutes

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Glycocins are the ribosomally synthesized glycosylated bacteriocins discovered and characterized in firmicutes, only. These peptides have antimicrobial activity against several pathogenic bacteria, including Streptococcus pyrogenes, Methicillin-resistant Staphylococcus aureus and food-spoilage

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