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6 results
Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1β-stimulated SK-N-SH neuronal cells.
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BACKGROUND
The dried seed of Picralima nitida is used in rheumatic fever and as an antipyretic in West Africa. In this study we have investigated the effects of an extract obtained from the seeds of Picralima nitida (PNE) on PGE2 production in IL-1β-stimulated cells.
METHODS
Prostaglandin E2 (PGE2)
Medicinal uses, phytochemistry and pharmacology of Picralima nitida (Apocynaceae) in tropical diseases: a review.
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Picralima nitida Durand and Hook, (fam. Apocynaceae) is a West African plant with varied applications in African folk medicine. Various parts of the plant have been employed ethnomedicinally as remedy for fever, hypertension, jaundice, dysmenorrheal, gastrointestinal disorders and malaria. In order
Anti-inflammatory, antipyretic and anti-malarial activities of a West African medicinal plant--Picralima nitida.
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A preliminary pharmacological screening of the methanolic extract of Picralima nitida fruit was carried out. The extract showed potent and dose-dependent anti-inflammatory, antipyretic and anti-malarial activities. Given intraperitoneally, it inhibited carrageenan-induced rat paw oedema with IC50 of
Medicinal Uses and Natural Availability of Three Plant Species in Selected Ecosystems in Cameroon.
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In many developing countries traditional medicine constitutes a major part of health care because of its local availability and affordability compared to modern medicine. However, little is known about the specific uses and availability of medicinal plants. In this research an exploratory study was
Antimalarial activity in crude extracts of some Cameroonian medicinal plants.
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Fifteen crude extracts from the stem bark and seeds of four medicinal plants, viz: Entandrophragma angolense, Picralima nitida, Schumanniophyton magnificum and Thomandersia hensii were tested in vitro for their antimalarial activity against the chloroquine-resistant Plasmodium falciparum W2 strain.
Potential inhibition of major human cytochrome P450 isoenzymes by selected tropical medicinal herbs-Implication for herb-drug interactions.
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