Anisatin, a toxic sesquiterpene isolated from the Japanese star anise (Illicium anisatum L.), competitively inhibited the specific binding of [3H]4'-ethynyl-4-n-propylbicycloorthobenzoate ([3H]EBOB), a non-competitive antagonist of gamma-aminobutyric acid (GABA)A receptors, to rat brain membranes
We investigated the effects of anisatin, a pure toxic substance isolated from Illicium anisatum, and chloride ion on [3H]muscimol binding to rat brain membranes at various temperatures (0-16 degrees C). Chloride ion (100 mM) itself slightly inhibited specific [3H]muscimol binding at 0-4 degrees C
The molecular structure of 2alpha-hydroxyneoanisatin, a positional isomer of the potent neurotoxin anisatin, was determined by X-ray crystallographic analysis. This compound and four further seco-prezizaane type sesquiterpene lactones previously isolated from Illicium floridanum, which represent
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