The extracellular matrix (ECM) that gives tissue its structural integrity is remodeled in skin aging/photoaging and cancer via the increased expression/activities of matrixmetalloproteinases (MMP), inhibition of the tissue inhibitors of matrix metalloproteinases (TIMP), or inhibition of collagen
BACKGROUND
UV radiation and the presence of melanocytic nevi are the main risk factors of sporadic melanoma (MM). Protection of skin by an oral photoprotective agent would have substantial benefits.
OBJECTIVE
We investigated the possible role of an oral Polypodium leucotomos (PL) extract to improve
Dietary supplements are commonly recommended by dermatologists in the treatment of skin, hair, and nail disorders. This review of oral over the counter (OTC) supplement use in dermatology summarizes current evidence for the use of zinc, biotin, vitamin D, nicotinamide, and polypodium in the
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