pouchitis/protease

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Fecal Proteases from Pouchitis Patients Activate Protease Activating Receptor-2 to Disrupt the Epithelial Barrier.

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The pathogenesis of pouch inflammation may involve epithelial barrier disruption. We investigated whether fecal proteolytic activity is increased during pouchitis and results in epithelial barrier dysfunction through protease activating receptor (PAR) activation, and assessed whether

Immunoglobulin G and albumin levels in whole gut lavage fluid provide an objective measure of pouch ileitis.

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BACKGROUND Gut protein loss is a characteristic of inflammatory bowel disease (IBD), and immunoglobulin (Ig) G, albumin and alpha1-antitrypsin concentrations in whole gut lavage fluid (WGLF) correlate with clinical disease activity. If inflammation in ileoanal pouches is similar to IBD, then

Pouchitis: result of microbial imbalance?

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To elucidate the role of microbiological factors in pouchitis, this study investigated the composition of ileal reservoir microflora, the mucus degrading capacity of bacterial enzymes as well as the pH and the proteolytic activity of pouch effluent. Stool samples were collected from five patients

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