spasmogenic/inflammation

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The analgesic, anti-inflammatory and calcium antagonist potential of Tanacetum artemisioides.

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Several species of the genus Tanacetum are traditionally used in a variety of health conditions including pain, inflammation, respiratory and gastrointestinal disorders. In the current investigation, we evaluated the plant extract of T. artemisioides and some of its pure compounds (flavonoids) for

Spasmogenic activity of chemotactic N-formylated oligopeptides: identity of structure--function relationships for chemotactic and spasmogenic activities.

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The chemotactic N-formylated oligopeptides are potent spasmogenic agents for guinea pig ileum. Structure-activity studies with various N-formylated peptides suggest the presence of a specific receptor that resembles in specificity the formyl peptide receptor on leukocytes. A competitive antagonist

Mechanisms of increased airway microvascular permeability: role in airway inflammation and obstruction.

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1. Airway inflammation is a signal feature of human asthma, as is bronchial obstruction and the resultant airflow limitation. An obligatory accompaniment to airway inflammation is increased airway microvascular permeability, which in turn is causally related to bronchial oedema. In this review, we

Helminth-induced intestinal inflammation.

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Gastrointestinal inflammation is a prominent feature of protective reactions in animals immune against helminths. Infiltration into the inflamed mucosa of various cells and their subsequent activation result in the elaboration of an array of pharmacologically and biologically active substances. The

[Influence of nonsteroidal anti-inflammatory preparations on the in vitro and in vivo effects of sodium arachidonate].

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It has been demonstrated on isolated guinea-pig ileum and rats that nonsteroid antiinflammatory drugs (acetylsalicylic acid, ibuprofen, diclofenac sodium, butadione, and indomethacin) antagonized spasmogenic and inflammatory effects of sodium arachidonate, but not of other mediators of inflammation

Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activity.

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CR3465 (L-Tyrosine, N-[(2-quinolinyl)carbonyl]-O-(7-fluoro-2-quinolinylmethyl) sodium salt) is a potent antagonist of [3H]leukotriene D4 ([3H]LTD4) binding to guinea pig lung preparations, its Ki (4.7+/-0.7 nM) being comparable with that of montelukast (5.6+/-0.6 nM). In tracheal strips from

The regulation of inflammatory mediator production by mast cell products.

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Mast cells are prominent in the airways and have been implicated in the pathophysiology of asthma. The ability of mast cells to generate or release the vasoactive/spasmogenic mediators histamine, adenosine, PGD2, sulfidopeptide leukotrienes, and platelet-activating factor is thought relevant to

Non-steroid anti-inflammatory drugs in asthma: dangerous or useful therapy?

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The therapeutic potential of non-steroid anti-inflammatory drugs in clinical asthma is offset by the real possibility of hypersensitivity and induction of severe airways obstruction. The influence of indomethacin on the antigen-induced asthmatic response was tested. Early and delayed asthmatic

Multiple sites of interaction between prostaglandins and non-steroidal anti-inflammatory agents.

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Several non-steroidal anti-inflammatory agents (NSAIA) are shown to inhibit the net production of prostaglandin (PG)- like activity from arachidonic acid by a cell-free preparation of guinea-pig lung. Moreover, these agents also antagonize PGE-1-induced contractions of the isolated gerbil colon. The

Mast cells and airway inflammation in asthma.

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A number of new observations have added to our understanding of mast cell biology and the relevance of this cell to the genesis of asthma. The purpose of this review has been to highlight this new information and to refer the reader to extensive reviews where previously documented and well-known

[Spasmolytic and anti-inflammatory activity of 8-hydroxyquinolines].

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It has been shown that quinozole (aqueous solution), enteroseptol and nitroxoline (suspension with Tween-80) in a concentration of 0.2 X 10(-6)-1.10(-5) decrease the tone of the rat and guinea-pig ileum and diminish their peristalsis. When administered in the same concentrations quinozole removes or

[Tobacco: an atherogenic, thrombogenic or spasmogenic factor?].

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Smoking is one of the major causes of morbidity and mortality in the developed world. The main cause of death related to smoking is myocardial infarction. Smoking not only accelerates the process of atherosclerosis but also predisposes to acute complications, early in atheromatous disease, and which

Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.

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In guinea-pig ileum (GPI), the chemotactic peptide N-formyl-Met-Leu-Phe-OH (fMLF) possesses spasmogenic properties through the activation of formyl peptide receptors (FPRs). Despite this, the mediators involved remain to be elucidated. fMLF (1nM-1μM) induced a dose-dependent contraction of GPI

Cysteinyl leukotriene D4 increases human detrusor muscle responsiveness to histamine.

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OBJECTIVE Leukotriene D(4) and histamine are proinflammatory mediators that are released concomitantly by activated mast cells. There is the possibility of mutual potentiation of their actions in inflammatory diseases such as interstitial cystitis. We investigated whether human detrusor smooth

Antihistamines in asthma.

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Substantial evidence indicates that airway hyperresponsiveness in asthma is associated with the inflammatory response directed toward the airway epithelium and submucosa. Endogenously released spasmogenic mediators interacting with smooth muscle have a greater effect on hyperresponsive than on

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