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stargardt disease/serotonin
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Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.
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A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human diseases and lead to therapy development. Here, we applied this strategy to identify pharmacological targets for the treatment of Stargardt
Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.
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Compromised clearance of all-trans-retinal (atRAL), a component of the retinoid cycle, increases the susceptibility of mouse retina to acute light-induced photoreceptor degeneration. Abca4(-/-)Rdh8(-/-) mice featuring defective atRAL clearance were used to examine the one or more underlying
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