stellera chamaejasme/anticancer

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[The antitumor activities of gnidimacrin isolated from Stellera chamaejasme L].

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Gnidimacrin, a diterpene compound, isolated from the methanol extract of Stellera chamaejasme L, showed significant antitumor activities against mouse leukemia P-388 and L-1210 in vivo. At the dosages of 0.02-0.03mg/kg ip, the in increase in life span (ILS) was 70% and 80%, respectively. Gnidimacrin

Mechanism of antitumor action of PKC activator, gnidimacrin.

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Daphnane-type diterpene gnidimacrin isolated from the Chinese plant Stellera chamaejasme L. is an antitumor agent that activates protein kinase C (PKC). The mechanism of antitumor action of gnidimacrin and the possible involvement of PKC were examined using sensitive K562 and refractory HLE cells.

[Antitumor components screening of Stellera chamaejasme L. under the case of discrete distribution of active data].

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This is to report the screening, extracting and validating antitumor components and compounds from Stellera chamaejasme L. under the case of discrete distribution of active data. In this work, different components from Stellera chamaejasme L. were collected by HPD macroporous resin and polyamide

In vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L.

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OBJECTIVE To examine the anti-cancer effects of chamaejasmenin B and neochamaejasmin C, two biflavonones isolated from the root of Stellera chamaejasme L (known as the traditional Chinese herb Rui Xiang Lang Du) in vitro. METHODS Human liver carcinoma cell lines (HepG2 and SMMC-7721), a human

Anti-tumor pharmacological evaluation of extracts from stellera chamaejasme L based on hollow fiber assay.

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BACKGROUND Stellera chamaejasme L, a traditional Chinese herb, has long been used for treatment of various tumors in the Chinese population. In our previous study, we paid an attention to the cytotoxic and proapoptotic effects of Stellera chamaejasme L extracts (ESC, ESC-1 and ESC-2, the latter two

[Anti-tumor effect of alcohol extract of Stellera chamaejasme in vitro].

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OBJECTIVE To observe the anti-tumor effect of alcohol extract of Stellera chamaejasme-AESC, AESC-1 and AESC-2 in vitro. METHODS Inhibition rates of AESC, AESC-1, AESC-2 on five tumor cells (A549, NCI-H157, NCI-H460, BEL-7402 and SK-HEP-1 cell lines) were observed and IC50, GI50, TGI50 and LC50 were

[Antitumor effect of alcohol extracts from Stellera chamaejasme].

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OBJECTIVE To screen the best antitumor components of Stellera chamaejasme and their sensitive cell lines. METHODS Sixteen different components of alcohol extracts from S. chamaejasme, including HH, H1-H8, JH and J1-J8, were got by gradient column chromatography eluted with alcohol in different

Antitumor activity of daphnane-type diterpene gnidimacrin isolated from Stellera chamaejasme L.

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The daphnane-type diterpene gnidimacrin, isolated from the root of the Chinese plant, Stellera chamaejasme L., was found to strongly inhibit cell growth of human leukemias, stomach cancers and non-small cell lung cancers in vitro at concentrations of 10(-9) to 10(-10) M. On the other hand, even at

[The antitumor effects of total-flavonoid from Stellera chamaejasmel].

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OBJECTIVE To study the antitumor effects of total-flavonoid from S. chamaejasmel. METHODS The in vitro antitumor activity against human cancer cell lines, such as stomach cancer SGC-7901, hepatocarcinoma BEL-7402 and leukemia HL-60, were determined by a MTT and clone formation assay. The in vivo

[The antitumor activities of the extracts from Stellera chamaejasmel L. in vitro by means of systematic solvent extraction].

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OBJECTIVE To screen the antitumor extract from Stellera chamaejasmel L.. METHODS The means of systematic solvent extraction was used to separate the 95% ethanol extract. The antitumor activities of the different extracts in vitro were analyzed with MTT assay. RESULTS The petroleum ether extract and

Apoptosis induced by chamaejasmine in human osteosarcoma cells through p53 pathway.

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Osteosarcoma cancer is one of the most lethal malignancies, and there is no effective preventive measure to date. Chamaejasmine is the major ingredient in Stellera chamaejasme L. Except its potent pain-relieving efficacy as reported, chamaejasmine also exerted its anti-tumor activity in several

Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.

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Three new compounds, including one daphnane diterpene (1), one sesquiterpene (6), and one lignan (7) have been isolated from the Stellera chamaejasme L., together with five other known compounds, including four daphnane diterpenenoids (2-5) and one lignan (8). The structures of the new compounds

Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts.

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Stellera chamaejasme, a famous toxic herb, has been used in traditional Chinese medicine to treat various diseases. For decades, increasing attention in modern pharmacological studies has been drawn to S. chamaejasme because of its potential anti-tumor, anti-virus, and anti-fungus activities.

The inhibition mechanism of the uptake of lamivudine via human organic anion transporter 1 by Stellera chamaejasme L. extracts.

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Stellera chamaejasme L. is a traditional Chinese medicine with a long history to treat stubborn skin ulcer, and it also has antiviral and antitumor effects. Neochamaejasmine B (NCB), Neochamaejasmine A (NCA) and Chamaechromone (CMC) are the major components in dried roots of Stellera chamaejasme L..

Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins.

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The biflavonoid isochamaejasmin is mainly distributed in the root of Stellera chamaejasme L. (Thymelaeaceae) that is used in traditional Chinese medicine (TCM) to treat tumors, tuberculosis, and psoriasis. Herein, isochamaejasmin was found to show similar bioactivity against Bcl-2 family proteins to

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