stellera chamaejasme/leukemia

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Inhibition of cell growth by Stellera chamaejasme extract is associated with induction of autophagy and differentiation in chronic leukemia K562 cells.

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Stellera chamaejasme has been used as a therapeutic plant for treatment of various inflammatory diseases and solid tumors. Our study was particularly interested in the differentiation inducing activity of the aerial parts of S.chamaejasme using human chronic leukemia cell line K562. The ethanol

Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins.

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The biflavonoid isochamaejasmin is mainly distributed in the root of Stellera chamaejasme L. (Thymelaeaceae) that is used in traditional Chinese medicine (TCM) to treat tumors, tuberculosis, and psoriasis. Herein, isochamaejasmin was found to show similar bioactivity against Bcl-2 family proteins to

[The antitumor activities of gnidimacrin isolated from Stellera chamaejasme L].

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Gnidimacrin, a diterpene compound, isolated from the methanol extract of Stellera chamaejasme L, showed significant antitumor activities against mouse leukemia P-388 and L-1210 in vivo. At the dosages of 0.02-0.03mg/kg ip, the in increase in life span (ILS) was 70% and 80%, respectively. Gnidimacrin

Antitumor activity of daphnane-type diterpene gnidimacrin isolated from Stellera chamaejasme L.

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The daphnane-type diterpene gnidimacrin, isolated from the root of the Chinese plant, Stellera chamaejasme L., was found to strongly inhibit cell growth of human leukemias, stomach cancers and non-small cell lung cancers in vitro at concentrations of 10(-9) to 10(-10) M. On the other hand, even at

[The antitumor effects of total-flavonoid from Stellera chamaejasmel].

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OBJECTIVE To study the antitumor effects of total-flavonoid from S. chamaejasmel. METHODS The in vitro antitumor activity against human cancer cell lines, such as stomach cancer SGC-7901, hepatocarcinoma BEL-7402 and leukemia HL-60, were determined by a MTT and clone formation assay. The in vivo

[The antitumor activities of the extracts from Stellera chamaejasmel L. in vitro by means of systematic solvent extraction].

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OBJECTIVE To screen the antitumor extract from Stellera chamaejasmel L.. METHODS The means of systematic solvent extraction was used to separate the 95% ethanol extract. The antitumor activities of the different extracts in vitro were analyzed with MTT assay. RESULTS The petroleum ether extract and

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