stemona saxorum/chemotherapy

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[Studies on chemotherapy of parasitic helminths (III). Effects of tuberostemonine from Stemona japonica on the motility of parasitic helminths and isolated host tissues (author's transl)].

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Effects of tuberostemonine (TS), an alkaloid from Stemona japonica, on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. 1) TS (6.7 X 10(-6) approximately 2 X 10(-5) M) paralyzed the motility of Angiostrongylus cantonensis. 2) TS (6.7 X 10(-5) M) showed

The dichloromethane fraction of Stemona tuberosa Lour inhibits tumor cell growth and induces apoptosis of human medullary thyroid carcinoma cells.

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Medullary thyroid carcinoma (MTC), a neuroendocrine tumor arising from the thyroid gland, is known to be poorly responsive to conventional chemotherapy. The root of Stemona tuberosa Lour, also called Bai Bu, is a commonly used traditional Chinese anti-tussive medicine. The present study investigated

Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance.

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P-glycoprotein-mediated drug efflux can cause a multidrug resistance (MDR) phenotype that is associated with a poor response to cancer chemotherapy. Through bioassay-guided fractionation, active Stemona alkaloids were isolated from the roots of Stemona aphylla and S. burkillii. The chemical

Overcoming P-Glycoprotein-Mediated Multidrug Resistance in Colorectal Cancer: Potential Reversal Agents among Herbal Medicines.

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UNASSIGNED Multidrug resistance (MDR) is the major reason for the failure of chemotherapy in colorectal cancer (CRC), and the primary determinant of MDR in CRC patients is active drug efflux owing to overexpression of P-glycoprotein (P-gp) in cancer tissues. Despite research efforts to overcome

Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships.

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BACKGROUND Multidrug resistance (MDR) is a major reason for the failure of chemotherapy in the treatment of cancer patients. P-gp over-expression in MDR cancer cells is a multifactorial phenomenon with biochemical resistance mechanisms. Stemofoline (STF), isolated from Stemona bukillii, has been

Activity of novel plant extracts against medullary thyroid carcinoma cells.

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BACKGROUND Medullary thyroid carcinoma (MTC) is a rare calcitonin-producing tumor, derived from the parafollicular C-cells of the thyroid. MTC is known to be relatively insensitive to conventional chemotherapy. METHODS Eight cell lines were established from MTCs; each showed an up-regulation of

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