thiouracil/atrophy

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Atrophy of adrenal gland following thiouracil and vitamin B12.

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[The question of malignant degeneration of the thyroid gland treated with methyl thiouracil].

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Cellular involution in the thyroid gland; significance of Hürthle cells in myxedema, exhaustion atrophy, Hashimoto's disease and the reactions to irradiation, thiouracil therapy and subtotal resection.

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Validation of a quantitative method using liquid chromatography coupled to multiple mass spectrometry for thiouracil in feedstuffs used in animal husbandry.

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The use of thyreostatic drugs, like thiouracil (TU), in animal production has been banned for over three decades by the European Union, due to potential teratogenic and carcinogenic effects of its residues upon human consumption. Besides, thyreostats induce water retention in livestock, causing

The effects of 4-methyl-2-thiouracil on fibre type and cross-sectional area in the soleus muscle of the rat.

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The effects of 4-methyl-2-thiouracil (MTU, 0.1% in drinking water) on the composition and cross-sectional area of muscle fibres of the rat soleus muscle were studied. The percentage of fast twitch-oxidative-glycolytic (FOG) fibres fell after 2 weeks of treatment with MTU to zero at 8 weeks. In

Cu(II) adsorption on 2-thiouracil-modified Luffa cylindrica biochar fibres from artificial and real samples, and competition reactions with U(VI).

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The adsorption of Cu(II) ions by biochar fibres prior and after modification with 2-thiouracil on real and artificial samples has been studied by batch-type adsorption experiments, FTIR and XPS spectroscopy and competition reactions using U(VI) ions as competitor cations. The experimental data of

Observations on the fine structure of propylthiouracil-induced "brown degeneration" in the zona reticularis of mouse adrenal cortex.

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Propylthiouracil (6-propyl-2-thiouracil), an anti-thyroid agent, was fed to mice in a concentration equal to 0.1% of their diet for periods of 10 and 15 weeks. The cells of the inner zone of the adrenal cortex were examined with the electron microscope. In animals receiving propylthiouracil for ten

Preliminary evaluation of an in utero-lactation assay using 6-n-propyl-2-thiouracil.

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In this preliminary study, the potential of an in utero-lactation assay to detect thyroid effectors was evaluated by treating three dams/group with 6-n-propyl-2-thiouracil (PTU), a known thyroid antagonist, by oral gavage at doses of 0, 0.0032, 0.016, 0.08 and 0.4 mg/kg/day during fetal

Hypothyroidism in the adult rat causes incremental changes in brain-derived neurotrophic factor, neuronal and astrocyte apoptosis, gliosis, and deterioration of postsynaptic density.

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BACKGROUND Adult hypothyroidism is a highly prevalent condition that impairs processes, such as learning and memory. Even though tetra-iodothyronine (T(4)) treatment can overcome the hypothyroidism in the majority of cases, it cannot fully recover the patient's learning capacity and memory. In this

Combinatorial minimization and secondary structure determination of a nucleotide synthase ribozyme.

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We previously isolated from random sequences ribozymes able to form a glycosidic linkage between a ribose sugar and 4-thiouracil in a reaction that mimics protein-catalyzed nucleotide synthesis. Here we report on two serial in vitro selection experiments that defined the core motif of one of the

Neonatal hypothyroidism-induced changes in rat testis size, dependence on temperature.

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OBJECTIVE Effects of transient neonatal hypothyroidism (HPOT) on adult testis size and serum hormone profiles were evaluated in the Charles foster strain of rats, maintained under the temperature of 21 degrees C (HPOTL) or of 34 degrees C (HPOTH). METHODS Hypothyroidism was induced in suckling pups

The goitrogen 3-hydroxy-4(1H)-pyridone, a ruminal metabolite from Leucaena leucocephala: effects in mice and rats.

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Mice fed a diet containing 1% (w/w) 3-hydroxy-4(1H)-pyridone (DHP) developed goitre even with a diet high in iodine whereas mimosine (0.5% w/w) did not produce goitre even with a low-iodine diet. Thyroid enlargement was apparent (measured morphometrically) by the 7th week and was advanced by the

[Thyroid hormone autoantibodies in Hashimoto's disease and Graves' disease].

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We previously reported the presence of thyroid hormone autoantibodies (THAA) in the sera from three (2 Hashimoto's thyroiditis, 1 Hashimoto's thyroiditis suspected) out of four sisters in a family and one patient with Graves' disease during treatment with methimazole (MMI). According to the

Light and ultrastructural study in the propylthiouracil-induced hypothyroid rat heart ventricles and the ameliorating role of folic acid.

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Thyroid hormones have marked effects on the growth, development, and metabolic function of virtually all organs and tissues. Thyroid status is an important determinant of cardiovascular function. The present work studied the histopathological and ultrastructural changes in the hypothyroid rat left

[The effect of carbamide feeding over a long period of time on thyroid gland activity in bulls].

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In this experiment, 10 fattening bulls were given 0.27-0.42 g/kg body-weight of urea daily for 4 months. The bulls slaughtered after the experiments showed enlarged thyroid glands. These thyroid glands were much larger than the control glands (P = 0.1%). At the end of the experiment the bulls fed

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