ulex/hypoxia

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Implications on glycobiological aspects of tumor hypoxia in breast ductal carcinoma in situ.

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Breast carcinoma is one of the most common neoplasia and the first cause of women cancer related deaths worldwide. In the past few years with diagnostic increment, the number of patients diagnosed with ductal carcinoma in situ (DCIS) increased considerably and opened up new ways in research and new

VEGF-, KIT protein- and neutral endopeptidase (NEP/CD10)-positive myofibroblasts-precursors of angiogenesis in chorioangiomas?

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Chorioangiomas are benign angiomatous tumours of the placenta occurring with a frequency of approximately one per cent of all examined placentae. Hypoxia and genetic factors are discussed to be predisposing factors for chorioangiomas. However, not much is known about the tumorigenesis of these

Identification of the connective tissues synthesized by the venous and arterial endothelia of the human umbilical cord: a comparative study.

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Immunocytochemistry has been used to identify endothelial cells in sections of human umbilical cord and in cultures of the venous and arterial endothelium, using Factor VIII and Ulex europaeus as endothelial markers. The connective tissue components, including various collagen types, fibronectin and

Myocyte/capillary mismatch in the heart of uremic patients.

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Experiments indicate that capillary density is reduced in the hypertrophied left ventricle of rats with subtotal nephrectomy compared to control rats with similar BP and left ventricular hypertrophy, suggesting that in uremia, hypertrophying cardiomyocytes outgrow their capillary supply. No

Renal medullary carcinoma: clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications.

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OBJECTIVE To investigate the pathologic, clinical, and genetic features of renal medullary carcinomas (RMCs) in search of clues to their pathogenesis. METHODS We analyzed 40 RMCs for clinical features, for immunohistochemical expression using a panel of markers, and for genetic changes using

Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells.

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Functional endothelial-like cells (EC) have been successfully derived from different cell sources and potentially used for treatment of cardiovascular diseases; however, their relative therapeutic efficacy remains unclear. We differentiated functional EC from human bone marrow mononuclear cells

Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry.

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Tissue sections from aggressive human intraocular (uveal) and metastatic cutaneous melanomas generally lack evidence of significant necrosis and contain patterned networks of interconnected loops of extracellular matrix. The matrix that forms these loops or networks may be solid or hollow. Red blood

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