Gum arabic (GA), the dried exudates of Acacia seyal and Acacia senegal trees, being a biopolymer, has found many applications in the food, pharmaceutical, cosmetic, and lithography industries. GA, a water-soluble food hydrocolloid, is a complex and variable mixture of arabinogalactan
OBJECTIVE
Protein tyrosine phosphatase 1B (PTP 1B) and dipeptidyl peptidase IV (DPP IV) have been identified as one of the drug targets for the treatment of Type-2 diabetes. This study was designed to screen for PTP 1B and DPP-IV inhibitors from some Nigerian medicinal plants.
METHODS
PTP 1B and
Epidermal growth factor (EGF) is a 53-amino acid polypeptide that is known to produce a number of biologic effects both in vitro and in vivo. High concentrations of EGF are found in urine, and high concentrations of prepro-EGF mRNA have been detected in kidney, localized to thick ascending limb of
OBJECTIVE
To exploit the potential of endophytic fungi for pharmaceutically important antidiabetic alpha glycosidase inhibitors.
RESULTS
Thirty six endophytic fungi were isolated from Acacia nilotica and screened for the production of alpha amylase and glucosidase inhibitors. Inhibitory activity
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