Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients
Palabras clave
Abstracto
Descripción
BACKGROUND Peritoneal surfaces are the second most common site of disease progression for colorectal cancer (CRC), following liver metastases. Historically, prognosis of CRC peritoneal metastases (PM) was only about 6 months with palliative systemic chemotherapy or supportive care. Survival improvements have been reported with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). However, CRS/HIPEC is more effective and safe when early-stage CRC-PM are treated and most patients are not suitable for CRS/HIPEC, due to extensive peritoneal and/or systemic disease. Also, in the palliative setting, modern systemic therapies appear to be less effective for PM, than non-PM metastatic CRC and absence of symptoms and current limitations of imaging hamper early diagnosis and treatment of PM. These points would support the use of adjuvant HIPEC to prevent the outgrowth of occult peritoneal seeding into macroscopic disease.
STUDY DESIGN This tudy to assesses feasibility and safety of an integrated approach of curative surgery and adjuvant HIPEC performed at the same time as primary surgery in patients with primary CRC at high risk for the development of metachronous PM. Patients are prospectively selected on the base of preoperative clinical and radiological work-up. At surgery, careful exploration of all peritoneal the cavity, and intra-operative pathological examination are carried out to confirm clinical-pathological risk-factors for PM development Standard adjuvant systemic chemotherapy is intended in the postoperative setting. A matched control group will be selected among patients with colorectal cancer undergoing curative surgery and standard adjuvant systemic chemotherapy at the same institution and during the same period.
STUDY POPULATION Patients with colorectal cancer undergoing intentionally curative resection for primary tumors infiltrating the visceral serosa (T4a) or directly invading adjacent organs (T4b), with positive peritoneal washing cytology or resected ovarian or minimal peritoneal metastases.
INTERVENTION Adjuvant HIPEC procedure is performed under general anaesthesia after the completion of the surgical procedures. Colon resections for primary tumors are performed according to the oncologic principles of adequate lymph-adenectomy.Greater and lesser omentectomy and adhesiolysis (if necessary) are performed routinely to ensure optimal perfusion during the HIPEC. Tumor deposits on visceral and parietal surfaces are surgically removed by formal peritonectomy procedures and/or organ resections, as needed. HIPEC is performed with cisplatin (25 mg/m2/l of perfusate) and mitomycin-C (3•3 mg/m2/l of perfusate) at 42•5°C for 60 minutes according to the closed-abdomen .technique.
OUTCOMES Primary end-point is the sensitivity and false positive rate of preoperative/intraoperative assessment of primary tumor-related risk-factors for the development of peritoneal metastases in patients with colorectal cancer undergoing curative surgery..Secondary endpoints are number of participants with adverse events as a measure of safety and tolerability, Cumulative incidence of PM, overall and progression-free survival are assessed in comparison with matched controls.
fechas
| Verificado por última vez: | 08/31/2015 |
| Primero enviado: | 09/20/2015 |
| Inscripción estimada enviada: | 10/12/2015 |
| Publicado por primera vez: | 10/14/2015 |
| Última actualización enviada: | 10/12/2015 |
| Última actualización publicada: | 10/14/2015 |
| Fecha de inicio real del estudio: | 12/31/2005 |
| Fecha estimada de finalización primaria: | 05/31/2010 |
| Fecha estimada de finalización del estudio: | 11/30/2011 |
Condición o enfermedad
Intervención / tratamiento
Drug: Adjuvant HIPEC
Procedure: Adjuvant HIPEC
Fase
Grupos de brazos
| Brazo | Intervención / tratamiento |
|---|---|
| Experimental: Adjuvant HIPEC Adjuvant HIPEC will be performed simultaneously with primary tumor resection in patients undergoing curative surgery for primary colorectal cancer associated with risk factors for the development of metachronous peritoneal metastases. | Drug: Adjuvant HIPEC Closed-abdomen HIPEC with cisplatin (25 mg/m2/l of perfusate) and mitomycin-C (3•3 mg/m2/l of perfusate) at 42•5°C for 60 minutes. Perfusate volume: 4-6 l. |
| No Intervention: Matched control Comparable controls will be retrospectively selected from patients undergoing curative surgery for colorectal cancer at the National Cancer Institute (Milan, Italy) during the same period.
Every single control patient will be matched with a.patient in HIPEC group according to the following criteria: i) risk-factor for metachronous PM (minimal synchronous PM vs. ovarian metastases vs. pathological tumor [pT] stage (pT4a/b); ii) pathological node (pN) stage (pN0 vs. pN1/2); iii) grading (well/moderately vs. poorly differentiated); iv) histological subtype (adenocarcinoma vs. mucinous/signet ring cell carcinoma); v) sex; vi) age (+/-5 years). The investigators will be blinded to patient outcomes during the process. |
Criterio de elegibilidad
| Edades elegibles para estudiar | 18 Years A 18 Years |
| Sexos elegibles para estudiar | All |
| Acepta voluntarios saludables | si |
| Criterios | Inclusion Criteria: - pathologically confirmed colorectal carcinoma; - curative surgery; - presence of at least one of the following risk-factors for the development of metachronous PM: - minimal synchronous PM (nodules ≤1cm in the omentum and/or close to the primary tumor), completely resected at the same time as primary tumor; - synchronous ovarian metastases, also resected at the same time as primary tumor; - primary tumor either penetrating visceral peritoneum (T4a), - primary tumor directly invading other organs (T4b); - signature of an informed consent form. - intention to start adjuvant systemic therapy and postoperative follow-up; - performance status ≤2 according to the Eastern Cooperative Oncology Group score; - no significant co-morbidities. - no active sepsis - no impaired cardiac function (history of previous cardiac failure, or ejection fraction <40%) - no impaired renal function (serum creatinin > 1.5 normal value or creatinin clearance < 60 mL/min); - no impaired hepatic function (serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, bilirubin > 1.5 normal value); - no impaired bone marrow function (leucocytes < 4000/mm3 ; neutrophils < 1500/mm3; platelet < 80000/mm3) - no impaired lung function (diagnosis of severe chronic obstructive pulmonary disease , or forced expiratory volume at one second < 50% or a diffusion capacity of lung for carbon monoxide < 40% age adjusted). Exclusion Criteria: - extensive PM (nodules >1cm, and/or nodules outside the omentum and/or beyond the close vicinity of the primary tumor); - extra-abdominal/hepatic metastases; - emergency presentation (bleeding, perforated, or occlusive primary); - bleeding diathesis or coagulopathy - history of previous neoplasm during the past three years, excluding skin spinocellular/basocellular carcinoma; - preoperative pelvic radio-chemotherapy |
Salir
Medidas de resultado primarias
1. Positive predictive value of preoperative/intraoperative assessment of primary tumor-related risk factors for the development of metachronous peritoneal metastases in patients undergoing curative surgery for colorectal cancer. [The primary outcome measure is assessed at an average of one week after the operation, at the time the pathological examination of surgical specimens is expected to be completed.]
Medidas de resultado secundarias
1. Number of patients with postoperative treatment-related adverse events. [60 days]
2. Peritoneal progression-free survival [36 months]
Otras medidas de resultado
1. Overall survival [36 months]
2. Progression-free survival [36 months]
