Antiplatelet Resistance Research in Patients With Peripheral Arterial Revascularization
Palabras clave
Abstracto
Descripción
In peripheral arterial disease, several studies have shown that the existence of an APR is predictive of the occurrence of thrombotic events but not all. The investigators can therefore ask the question of the benefit of adaptation of antiplatelet therapy by biological monitoring to prevent the recurrence of thrombotic events. The platelet aggregation tests used mainly concern aspirin, via stimulation with arachidonic acid, or anti-P2Y12 (clopidogrel, ticagrelor, prasugrel), via stimulation with adenosine diphosphate (ADP). For the latter, a test via the measurement of the phosphorylation of a cytoplasmic protein called "VASP" is also used routinely, making it possible to further clarify the existence of platelet resistance to anti-P2Y12. Within the vascular medicine department, any discovery of a potential resistance to the anti-platelet treatment of a patient requires a therapeutic adaptation to overcome this phenomenon of "resistance", and to improve the phenomenon of anti-aggregation
fechas
| Verificado por última vez: | 07/31/2018 |
| Primero enviado: | 05/14/2019 |
| Inscripción estimada enviada: | 05/14/2019 |
| Publicado por primera vez: | 05/15/2019 |
| Última actualización enviada: | 05/16/2019 |
| Última actualización publicada: | 05/20/2019 |
| Fecha de inicio real del estudio: | 12/31/2017 |
| Fecha estimada de finalización primaria: | 02/28/2018 |
| Fecha estimada de finalización del estudio: | 03/30/2018 |
Condición o enfermedad
Fase
Grupos de brazos
| Brazo | Intervención / tratamiento |
|---|---|
| search for antiplatelet resistance Patients who were hospitalized in the vascular medicine department and who benefited from a search for antiplatelet resistance between April 2014 and November 2017. |
Criterio de elegibilidad
| Edades elegibles para estudiar | 18 Years A 18 Years |
| Sexos elegibles para estudiar | All |
| Método de muestreo | Non-Probability Sample |
| Acepta voluntarios saludables | si |
| Criterios | Inclusion Criteria: - Patients older than 18 years - All patients who were hospitalized in the vascular medicine department and who received a search for antiplatelet resistance between April 2014 and November 2017. Exclusion Criteria: - Opposition to participation in the study - Absence of follow-up after antiplatelet resistance testing |
Salir
Medidas de resultado primarias
1. Number of re-occlusion of the revascularization procedure [1 year]
Medidas de resultado secundarias
1. Number of cardiovascular events [1 year]
