Bioavailability of Xanthones From Mangosteen
Palabras clave
Abstracto
Descripción
Garcinia mangostana L. (mangosteen) is a tropical tree native to Southeast Asia. The pericarp of mangosteen fruit is used in traditional medicine to treat inflammation, infections, wounds, and diarrhea. The proposed health-promoting effects have been attributed to a family of polyphenols referred to as xanthones. Since its introduction into the United States, juices and products containing mangosteen fruit have become a top-selling botanical dietary supplement. This commercial success largely has been the result of aggressive marketing of health claims based on in vitro observations and anecdotal reports.
The purpose of this study was to determine the bioavailability of xanthones from mangosteen juice in adult human subjects. After an overnight fast of at least 10h, male and female subjects were admitted to the Ohio State University Clinical Research Center. Volunteers ingested 2 ounces of 100% mangosteen juice as part of a western-style breakfast. Pericarp particles accounted for 1% of the mass and 99% of total xanthone content in the juice. This dose provided 130 ± 2 mg total xanthones. Blood was collected prior to breakfast and 1,2,3,4,6,8 and 24h. Subjects were fed a mangosteen-free lunch and released from the unit after the 8h collection, refraining from mangosteen containing products until final collection of blood at 24h. Urine was collected for the 24 test period.
fechas
| Verificado por última vez: | 07/31/2011 |
| Primero enviado: | 08/25/2011 |
| Inscripción estimada enviada: | 08/25/2011 |
| Publicado por primera vez: | 08/28/2011 |
| Última actualización enviada: | 08/30/2011 |
| Última actualización publicada: | 09/01/2011 |
| Fecha de inicio real del estudio: | 10/31/2010 |
| Fecha estimada de finalización primaria: | 10/31/2010 |
| Fecha estimada de finalización del estudio: | 01/31/2011 |
Condición o enfermedad
Fase
Grupos de brazos
| Brazo | Intervención / tratamiento |
|---|---|
| Females ingesting mangosteen juice | |
| Males ingesting mangosteen juice |
Criterio de elegibilidad
| Edades elegibles para estudiar | 18 Years A 18 Years |
| Sexos elegibles para estudiar | All |
| Método de muestreo | Non-Probability Sample |
| Acepta voluntarios saludables | si |
| Criterios | Inclusion Criteria: - 5 female - 5 male - body mass index - normal renal function - non-smoking Exclusion Criteria: - smokers - acute or chronic diseases - history of gastrointestinal diseases - >/= 10% weight loss - dietary or herbal supplement within 6 months of study - pregnancy |
Salir
Medidas de resultado primarias
1. Xanthones in urine [0-24 hours]
Medidas de resultado secundarias
1. Xanthones in sera [0-24 hours]
