Kidney Biomarkers of Acute Kidney Injury in Patients With Knee Arthroplasty
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EstadoTerminado
Patrocinadores
Kuopio University Hospital
ENSAYO CLÍNICO: NCT02642731
BioSeek: NCT02642731
Palabras clave
Abstracto
Sensitive renal markers have been studied abundantly in connection with open heart, liver and transplantation surgery; however in major orthopaedic surgery their use is anecdotal. The aim of the present study is to evaluate use of sensitive renal markers, NGAL (Neutrophil gelatinase associated lipocalin ), KIM-1 (Kidney injury molecule- 1), LFABP (liver-type fatty acid-binding protein), and IL-18 (interleukin -18), in patients coming for elective TKA (total knee arthroplasty) as a pilot study before large study concerning acute kidney injury in orthopaedic surgery.
Descripción
Acute renal deterioration is a serious adverse event in elective surgery. Serum creatinine based diagnostics of acute kidney injury may delay diagnosis and produce false negative results since serum creatinine is affected by diet, muscle mass, used hydration therapy. In recent times new markers have been developed and tested in order to find sensitive, fast and reliable marker of renal deterioration.
fechas
| Verificado por última vez: | 01/31/2018 |
| Primero enviado: | 12/24/2015 |
| Inscripción estimada enviada: | 12/24/2015 |
| Publicado por primera vez: | 12/29/2015 |
| Última actualización enviada: | 02/24/2018 |
| Última actualización publicada: | 02/26/2018 |
| Fecha de inicio real del estudio: | 08/31/2013 |
| Fecha estimada de finalización primaria: | 11/30/2015 |
| Fecha estimada de finalización del estudio: | 11/30/2015 |
Condición o enfermedad
Arthroplasty, Replacement, Knee
Acute Kidney Injury
Fase
-
Grupos de brazos
| Brazo | Intervención / tratamiento |
|---|---|
| Patients for elective TKA patients with normal or near normal plasma creatinine who come for elective total knee arthroplasty |
Criterio de elegibilidad
| Edades elegibles para estudiar | 50 Years A 50 Years |
| Sexos elegibles para estudiar | All |
| Método de muestreo | Probability Sample |
| Acepta voluntarios saludables | si |
| Criterios | Inclusion Criteria: - informed consent - allergy to NSAIDs Exclusion Criteria: - no informed consent |
Salir
Medidas de resultado primarias
1. Renal function [time zero hours to 48 hours]
S-creatinine, Cystatin C, estimated GFR
Medidas de resultado secundarias
1. Concentraton of sensitive renal markers [time zero hours to 24 hours]
U-NGAL, P-NGAL, U-KIM-1, U-IL-18
