Pain in Adults With Autism Spectrum Disorder
Palabras clave
Abstracto
Descripción
Adults with autism without intellectual disability (IQ > 85) are matched with members of siblings and control group (sex and chronological age).
Pain reactivity (Visual analog scale,endogenous modulation systems, salivary cortisol, automatic nervous system and behavioral responses to thermal stimulation assessed by an inspired behavior scale.) in adult with autism is tested using an experimental model of pain. Excitatory and inhibitory modulation systems were elicited using a temporal summation test administered before and after activation of the Diffuse Noxious Inhibitory Control (DNIC) by means of a cold-pressor test.
Demographic and clinical data are also collected (sensory profile, sleep disorders and depression inventory).
fechas
| Verificado por última vez: | 09/30/2017 |
| Primero enviado: | 10/20/2014 |
| Inscripción estimada enviada: | 10/26/2014 |
| Publicado por primera vez: | 10/28/2014 |
| Última actualización enviada: | 10/10/2017 |
| Última actualización publicada: | 10/11/2017 |
| Fecha de inicio real del estudio: | 05/28/2015 |
| Fecha estimada de finalización primaria: | 04/04/2017 |
| Fecha estimada de finalización del estudio: | 04/04/2017 |
Condición o enfermedad
Intervención / tratamiento
Device: thermode
Fase
Grupos de brazos
| Brazo | Intervención / tratamiento |
|---|---|
| Experimental: high functioning Autism Thermal stimulation with test thermode Thermic stimulations (tonic heat pain stimulation and cold-pressor test) are used to test excitatory and inhibitory pain mechanisms with high functioning Autism | |
| Placebo Comparator: witness Thermic stimulations (tonic heat pain stimulation and cold-pressor test) are used to test excitatory and inhibitory pain mechanisms with a witness |
Criterio de elegibilidad
| Edades elegibles para estudiar | 18 Years A 18 Years |
| Sexos elegibles para estudiar | All |
| Acepta voluntarios saludables | si |
| Criterios | Non-specific inclusion criteria: - intellectual quotient >85 - consent form signed Inclusion Criteria autism group : - autism diagnosis (CIM 10) from multidisciplinary evaluation (ADI-r, ADOS) - sibling without autism or developmental disorder Non-specific Exclusion Criteria: - chronic pain - pregnancy, breast feeding - consent form no signed Exclusion criteria sibling and witness groups: - diagnosis of autism or developmental disorder |
Salir
Medidas de resultado primarias
1. Pain as assessed by Computerized Visual analog scale [one day]
Medidas de resultado secundarias
1. salivary cortisol [one day]
2. Behavioral response to thermal stimulation assessed by an inspired EDM-DI behavior scale [one day]
3. heart rate variability [one day]
