Stress-Induced Inflammation and Reward Processing
Palabras clave
Abstracto
Descripción
In this study we propose to examine the association between psychosocial stress, the stress-induced inflammatory response, and reward processing in a female undergraduate sample. Specifically, we will 1) examine effects of an acute psychosocial stressor on reward processing; 2) evaluate the association between stress-related changes in inflammation and reward processing; and 3) test key vulnerability factors that may moderate the association between stress and reward. To achieve these goals, this study will recruit 60 female undergraduate students to test effects of stress on reward processing in a 3.5 hour laboratory session. Participants will be randomly assigned to either experience a laboratory stressor or a placebo control, and will complete reward tasks 90 minutes post stress/placebo onset, at which point the peripheral inflammatory response to stress reaches its peak. The reward tasks are computerized behavioral tasks that assess three domains of reward processing: reward-learning, reward motivation, and reward sensitivity. Throughout the session, all participants will complete self-report measures of affect and provide blood and saliva samples for evaluation of the psychological and physiological stress response. Within one week prior to the session, participants will attend a 1 hour visit in which they complete baseline reward tasks and self-report questionnaires assessing mood, personality, early life stress, and health behaviors. In total, participants will complete two visits, with a duration of 4.5 hours. This study builds upon prior studies demonstrating immediate effects of acute stress on reward processing, and further tests for delayed effects of acute stress on reward processing. Furthermore, this will be the first study to examine inflammation as a mechanism linking stress to deficits in reward processing. Findings may inform theory of depression etiology and contribute to more specialized treatment that is targeted at specific symptoms of depression.
fechas
Verificado por última vez: | 01/31/2019 |
Primero enviado: | 01/30/2019 |
Inscripción estimada enviada: | 01/30/2019 |
Publicado por primera vez: | 02/03/2019 |
Última actualización enviada: | 01/31/2019 |
Última actualización publicada: | 02/04/2019 |
Fecha de inicio real del estudio: | 05/11/2017 |
Fecha estimada de finalización primaria: | 12/07/2017 |
Fecha estimada de finalización del estudio: | 05/08/2018 |
Condición o enfermedad
Intervención / tratamiento
Behavioral: Stress; Trier Social Stress Task
Behavioral: Placebo Trier Social Stress Task
Fase
Grupos de brazos
Brazo | Intervención / tratamiento |
---|---|
Experimental: Stress; Trier Social Stress Task 5 min challenging speech task, 5 min challenging math task; performed in front of evaluators | Behavioral: Stress; Trier Social Stress Task Standardized acute psychosocial stressor |
Active Comparator: Placebo Trier Social Stress Task 5 min speech task, 5 min math task; performed alone | Behavioral: Placebo Trier Social Stress Task Active control version of the TSST |
Criterio de elegibilidad
Edades elegibles para estudiar | 18 Years A 18 Years |
Sexos elegibles para estudiar | Female |
Acepta voluntarios saludables | si |
Criterios | Inclusion Criteria: - English fluency - Age 18-28 - Biologically female Exclusion Criteria: - Current illness - Presence or history of major medical conditions - Current or past diagnosis of alcohol use disorder - Use of tobacco - Use of immune-altering medications - Current pregnancy |
Salir
Medidas de resultado primarias
1. Probabilistic Reward Task - Reward Responsiveness [Pre-TSST/P-TSST and 90 min post-TSST/P-TSST]
2. Effort Expenditure for Rewards Task - Reward Motivation [Pre-TSST/P-TSST and 120 min post-TSST/P-TSST]
3. Attentional Bias Task [Pre-TSST/P-TSST and 110 min post-TSST/P-TSST]
Medidas de resultado secundarias
1. Effort Expenditure for Rewards Task - Reward Sensitivity [120 min post-TSST]
2. Face Morphing Task [Pre-TSST/P-TSST and 115 min post-TSST/P-TSST]
Otras medidas de resultado
1. Depressive symptoms [Change in depressive symptoms from study entry to 4-month follow-up]
2. Affective experience during the experimental session [Entry, pre-TSST/P-TSST; during TSST/P-TSST; 60, 90, 120, 150 min post TSST/P-TSST]