Tart Cherry Juice and Chronic Disease Risk
Palabras clave
Abstracto
Descripción
In this study, the investigators recruited at-risk individuals (n=10) who were overweight (25.0-29.9 kg/m2) and obese (> 30.0 kg/m2) and likely to exhibit one or more conditions associated with MetS. Participants were >18 years of age, not pregnant, not diabetic, with no unresolved infections or diseases (diabetes, CVD, IBD, cancer and liver disease), and nonsmokers. Histories of medication and dietary supplement use were collected and those taking anti-inflammatory or lipid-lowering medications were excluded. After enrollment, subjects were randomly assigned to consume daily either 240 mL (8 ounces) of authentic TCJ (R.W. Knudsen, Chico, CA) or a placebo beverage (commercial fruit punch; Great Value, Bentonville, AR) for 4 weeks. After a 2-week washout period, participants consumed the alternate beverage for 4 weeks in this 10-week 2x2 crossover, placebo-controlled dietary intervention. Subsequently, the investigators determined the effect of TCJ in at-risk participants on markers of lipidemia (HDL, LDL, triglycerides, VLDL, total cholesterol), glycemia (fasting insulin and glucose, HOMA, QUICKI, McAuley indirect indices), and inflammation (hsCRP, TNF-alpha, and ESR).
fechas
| Verificado por última vez: | 07/31/2018 |
| Primero enviado: | 08/15/2018 |
| Inscripción estimada enviada: | 08/15/2018 |
| Publicado por primera vez: | 08/19/2018 |
| Última actualización enviada: | 08/15/2018 |
| Última actualización publicada: | 08/19/2018 |
| Fecha de inicio real del estudio: | 08/20/2009 |
| Fecha estimada de finalización primaria: | 09/29/2011 |
| Fecha estimada de finalización del estudio: | 09/29/2011 |
Condición o enfermedad
Intervención / tratamiento
Dietary Supplement: Placebo
Dietary Supplement: Tart cherry juice (TCJ)
Fase
Grupos de brazos
| Brazo | Intervención / tratamiento |
|---|---|
| Placebo Comparator: Placebo Participants randomized to consume either placebo beverage or tart cherry juice at beginning of the study followed by a 2 week washout then switch over to the alternate beverage. Approximately half of participants began study consuming placebo beverage and the other half TCJ. | Dietary Supplement: Placebo Participants consumed placebo beverage for 4 weeks. |
| Experimental: Tart cherry juice (TCJ) Participants randomized to consume either placebo beverage or tart cherry juice at beginning of the study followed by a 2 week washout then switch over to the alternate beverage. Approximately half pf participants began study consuming placebo beverage and the other half TCJ. | Dietary Supplement: Tart cherry juice (TCJ) Participants consumed tart cherry juice (8 ounces; 240 mL) per day for four weeks. |
Criterio de elegibilidad
| Edades elegibles para estudiar | 18 Years A 18 Years |
| Sexos elegibles para estudiar | All |
| Acepta voluntarios saludables | si |
| Criterios | Inclusion Criteria: - This study was a 12-week 2 x 2 crossover, randomized, placebo-controlled dietary intervention in overweight and obese participants (BMI>25.0 kg/m2) who are more likely to exhibit >1 of the 5 risk conditions associated with metabolic syndrome (MetS). BMI was the minimal criterion for recruitment. Exclusion Criteria: - Participants were >18 years of age, not pregnant, not diabetic, with no unresolved infections or diseases (diabetes, CVD, IBD, cancer and liver disease), and nonsmokers. Histories of medication and dietary supplement use were collected and those taking anti-inflammatory or lipid-lowering medications were excluded. |
Salir
Medidas de resultado primarias
1. TCJ and hsCRP [4 weeks]
Medidas de resultado secundarias
1. fasting triglycerides [4 weeks]
