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B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients

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EstadoTerminado
Patrocinadores
University of Copenhagen
Colaboradores
Science, Toxicology & Technology, San Francisco, California

Palabras clave

Abstracto

The primary aim was to measure the effect of green tea extract, tyrosine and caffeine on energy expenditure, appetite ratings and spontaneous energy intake together with recording of side effects in healthy normal weight subjects.

Descripción

Background: Long-term weight maintenance of a weight loss is often unsuccessful. Often a weight regain is observed in most studies that could indicate that most subjects are not able to change their eating habits. There is a need for simple and safe methods to prevent weight gain and re-gain i.e. by increasing thermogenesis and decrease spontaneous energy intake (EI). Studies have shown that nutritional and food-related non-nutritional factors influence the adjustment of EI and EE as the compounds can enhance the diet-induced thermogenesis (DIT) and suppress appetite.

Method: The present study was designed as a 4-way crossover, randomised, placebo controlled, dou-ble-blind study. Each treatment was separated by >3 d washout period. All treatments were administered as tablets containing either 500 mg green tea extract (whereof 125 mg cate-chins), 400 mg tyrosine, 50 mg anhydrous caffeine, or placebo.

on each test day body weight and composition was assessed. All participants underwent a 4.5-h assessment of energy expenditure by indirect calorimetry in a ventilated hood. Energy intake recorded of an ad libitum pasta salad brunch served after the last hood measurement

Subjects: Twelve healthy lean (20

fechas

Verificado por última vez: 11/30/2000
Primero enviado: 03/12/2006
Inscripción estimada enviada: 03/12/2006
Publicado por primera vez: 03/13/2006
Última actualización enviada: 03/12/2006
Última actualización publicada: 03/13/2006
Fecha de inicio real del estudio: 12/31/1999
Fecha estimada de finalización del estudio: 11/30/2000

Condición o enfermedad

Obesity

Intervención / tratamiento

Drug: tyrosine, green tea, caffeine

Fase

Fase 1

Criterio de elegibilidad

Edades elegibles para estudiar 18 Years A 18 Years
Sexos elegibles para estudiarMale
Acepta voluntarios saludablessi
Criterios

Inclusion Criteria:

- Twelve healthy and normal-weight men (age: 23.72.6 y, BMI: 22.41.8 kg/m2) participated in the study. They were weight stable (within 3-kg in last 3 mo), non-smoking, non-athletic, and had no use of dietary supplements or frequent use of medication.

Exclusion Criteria:

-

Salir

Medidas de resultado primarias

1. heart rate [undefined]

2. blood pressure [undefined]

3. enegy expenditure [undefined]

4. energy intake [undefined]

5. subjective appetite sensations [undefined]

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