CMV Disease and IRIS in HIV-1 Infected Persons
Palabras clave
Abstracto
Descripción
At present, human cytomegalovirus (HCMV) remains a major health threat in immune compromised patients. Especially HCMV will cause blind and death in HIV-1 infected person. Currently, few antiviral drugs can be chosen for treatment of HCMV infection. Besides, more and more drug resistant virus strains were reported and led failure in antiviral therapy.
Various diagnostic methods are available for CMV infection. Such as shell vial assay, CMV antigen test, pp65 antigen assay and polymerase chain reaction. But none of them could be a standard and highly valuable. Although CMV-PCR is very sensitive, it can't distinguish between active disease and asymptomatic infection or latency, can't predict symptomatic disease nor can't monitor the successful antiviral therapy.
Our first goal is to setup a series of molecular diagnostic tools for HIV-1 infected person. By using these tools, physicians can easily select cases with CMV disease or immune restoration inflammatory syndrome (IRIS) to enroll this study. Furthermore, we will seek for a predict marker for CMV reactivation, CMV disease and IRIS. Finally, our research will focus on the mechanism of the IE gene alternative splicing between lytic and latent stage. We may find out new therapeutic concept and prevent virus reactivation from latency.
fechas
Verificado por última vez: | 04/30/2008 |
Primero enviado: | 04/03/2007 |
Inscripción estimada enviada: | 04/03/2007 |
Publicado por primera vez: | 04/04/2007 |
Última actualización enviada: | 01/31/2009 |
Última actualización publicada: | 02/02/2009 |
Fecha de inicio real del estudio: | 10/31/2006 |
Fecha estimada de finalización primaria: | 06/30/2008 |
Fecha estimada de finalización del estudio: | 06/30/2008 |
Condición o enfermedad
Intervención / tratamiento
Genetic: IE gene
Fase
Criterio de elegibilidad
Sexos elegibles para estudiar | All |
Acepta voluntarios saludables | si |
Criterios | Inclusion Criteria: - Clinical diagnosis of HIV-1 Disease - Clinical diagnosis of CMV disease or immune restoration inflammatory syndrome (IRIS) |