Diagnostics for the Reperfusion Injury Following MI
Palabras clave
Abstracto
Descripción
By reperfusion of ischemic myocardium further tissue damage occurs (ischemia / reperfusion injury). Various contributing mechanisms have been discussed in experimental studies, e.g. disturbances in coronary microcirculation and consecutive induction of inflammatory cascades involving formation of reactive oxygen species. The ischemia / reperfusion injury causes diastolic and regional as well as global systolic dysfunction. The time course of the reperfusion injury within the first hours after reperfusion and its effects on the global geometry of the left ventricle have not been investigated so far. In the present study a comprehensive morphological and functional characterisation of the ischemia / reperfusion injury in the acute phase is performed. New cardiac imaging modalities (2D, 3D echocardiography, contrast echocardiography, strain analysis and cardiac MRI)and biochemical parameters including the L-arginine-nitric oxide pathway and inflammatory cascades are applied. Hereby morphological and biochemical markers for the functional recovery of myocardial function should be identified.
fechas
Verificado por última vez: | 02/28/2009 |
Primero enviado: | 09/11/2007 |
Inscripción estimada enviada: | 09/11/2007 |
Publicado por primera vez: | 09/13/2007 |
Última actualización enviada: | 03/18/2009 |
Última actualización publicada: | 03/19/2009 |
Fecha de inicio real del estudio: | 08/31/2007 |
Fecha estimada de finalización primaria: | 02/28/2009 |
Fecha estimada de finalización del estudio: | 02/28/2009 |
Condición o enfermedad
Intervención / tratamiento
Drug: 1
Procedure: 1
Procedure: 1
Procedure: blood sampling
Fase
Grupos de brazos
Brazo | Intervención / tratamiento |
---|---|
1 - patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery | Drug: 1 directly after PCI, at 24 h after PCI, before discharge and at 6 months |
2 - 30 patients with stable CAD (control group 1) | |
3 - 30 healthy volunteers regarding cardiovascular diseases (control group 2) |
Criterio de elegibilidad
Edades elegibles para estudiar | 18 Years A 18 Years |
Sexos elegibles para estudiar | All |
Método de muestreo | Non-Probability Sample |
Acepta voluntarios saludables | si |
Criterios | Inclusion Criteria: - patients with acute ST elevation myocardial infarction and consecutive percutaneous coronary intervention of the infarct-related artery (first myocardial infarction and recurrent myocardial infarction, as long as infarct-related artery is occluded for the first time) - written informed consent or 30 patients with stable CAD (control group 1) or 30 healthy volunteers regarding cardiovascular diseases (control group 2) Exclusion Criteria: - minors - incompetent persons - pregnant and lactating - moderate to severe renal insufficiency defined by an GFR < 60 ml/kg/m2 - missing written consent - other reasons complicating a clinical reevaluation and/or coronary angiography |