Intervention With Legume Kernel Fibre in Healthy Subjects
Palabras clave
Abstracto
Descripción
Dietary fibre is suspected to effect the faecal concentration and excretion of bile acids by binding the bile acids and by increasing the faecal mass. Bile acids, especially the secondary bile acids, are potential risk factors for colorectal cancer. A high bile acid-binding ability of fibre could lead to lower serum cholesterol concentrations by interrupting the enterohepatic circulation. There is evidence that the consumption of legume kernel fibre, containing both soluble and insoluble fibre fractions, may beneficially modify bowel health.
Seventy-eight healthy volunteers were enrolled. Seventy-six subjects (mean age of 24 years, 55 women and 21 men) completed the double-blind, randomized crossover trial. After two weeks run-in period, half of the volunteers consumed 25 g of legume fibres (Boregine, TypTop or Soy fibre) every day, and the other half received a reference fibre product (citrus fibre, Herbacel AQ Plus) for a period of two weeks. After two weeks wash-out the intervention changed between the groups.
At the end of each period a quantitative stool and urine collection took place and fasting blood samples were drawn.
fechas
| Verificado por última vez: | 11/30/2009 |
| Primero enviado: | 12/16/2009 |
| Inscripción estimada enviada: | 12/17/2009 |
| Publicado por primera vez: | 12/20/2009 |
| Última actualización enviada: | 11/04/2012 |
| Última actualización publicada: | 11/05/2012 |
| Fecha de inicio real del estudio: | 06/30/2007 |
| Fecha estimada de finalización primaria: | 11/30/2007 |
| Fecha estimada de finalización del estudio: | 11/30/2007 |
Condición o enfermedad
Intervención / tratamiento
Dietary Supplement: pure fibre-product
Dietary Supplement: reference fibre
Fase
Grupos de brazos
| Brazo | Intervención / tratamiento |
|---|---|
| Experimental: TypTop Lupinus albus Typ Top (lupin kernel fibre, dietary fibre content: 83%) | |
| Experimental: Soy fibre Glycine max Hefeng (soy fibre; dietary fibre content: 77%) | |
| Experimental: Boregine Lupinus angustifolius Boregine (lupin kernel fibre, dietary fibre content: 87%) |
Criterio de elegibilidad
| Edades elegibles para estudiar | 20 Years A 20 Years |
| Sexos elegibles para estudiar | All |
| Acepta voluntarios saludables | si |
| Criterios | Inclusion Criteria: - age 20-45 years - healthy subjects Exclusion Criteria: - intake of pharmaceuticals and nutritional supplements - allergy against legumes - intolerance against milk protein - pregnancy, lactation - chronic diseases |
Salir
Medidas de resultado primarias
1. Changes of serum lipids (cholesterol metabolism) [after 2, 4 and 8 weeks]
Medidas de resultado secundarias
1. Changes of general excretion parameters, neutral sterols, bile acids, short-chain fatty acids, fibre excretion [after 2, 4 and 8 weeks]
