Intervention With Lupin Kernel Fibre in Hypercholesterolemic Subjects
Palabras clave
Abstracto
Descripción
Dietary fibre is suspected to effect the faecal concentration and excretion of bile acids by binding the bile acids and by increasing the faecal mass. Bile acids, especially the secondary bile acids, are potential risk factors for colorectal cancer. A high bile acid-binding ability of fibre could lead to lower blood cholesterol concentrations by interrupting the enterohepatic circulation. There is evidence that the consumption of lupin kernel fibre, containing both soluble and insoluble fibre fractions, may beneficially modify bowel health.
A total of 133 subjects were recruited for this study. Sixty moderate hypercholesterolemic volunteers (total cholesterol > 5.2 mmol/L) fulfilled the selection criteria and were randomly assigned three groups. Forty-five subjects (mean age of 47 years, 34 women and 20 men) completed the double-blind, randomized crossover trial.
The subjects consumed a high-fibre diet containing 25 g fibre (citrus- or lupin fibre) per day and a low-fibre diet (placebo) for four weeks each. After baseline, each volunteer had to pass all three periods in different order with a two-week wash-out period between each.
At the end of each intervention period, subjects consumed a standardized diet for three days. Furthermore, a quantitative stool collection took place and fasting blood samples were drawn.
fechas
| Verificado por última vez: | 11/30/2012 |
| Primero enviado: | 12/16/2009 |
| Inscripción estimada enviada: | 12/16/2009 |
| Publicado por primera vez: | 12/17/2009 |
| Última actualización enviada: | 12/03/2012 |
| Última actualización publicada: | 12/04/2012 |
| Fecha de inicio real del estudio: | 05/31/2008 |
| Fecha estimada de finalización primaria: | 11/30/2008 |
| Fecha estimada de finalización del estudio: | 11/30/2008 |
Condición o enfermedad
Intervención / tratamiento
Dietary Supplement: fabricated food
Fase
Grupos de brazos
| Brazo | Intervención / tratamiento |
|---|---|
| Experimental: Boregine Intervention: Lupinus angustifolius Boregine; 25 g lupin kernel fibre per day over 4 weeks; lupin kernel fibre was incorporated in different food | |
| Active Comparator: Reference Intervention: Reference fibre (citrus fibre: Herbacel AQ Plus; Herbafood ingredients); 25 g citrus fibre per day over 4 weeks; the citrus fibre was incorporated in different food | |
| Placebo Comparator: Placebo different food without added fibre |
Criterio de elegibilidad
| Edades elegibles para estudiar | 20 Years A 20 Years |
| Sexos elegibles para estudiar | All |
| Acepta voluntarios saludables | si |
| Criterios | Inclusion Criteria: - moderate Hypercholesterolemia (total cholesterol > 5.2 mmol/L) - age 20-75 years Exclusion Criteria: - intake of lipid-lowering pharmaceuticals - intake of nutritional supplements - allergy against legumes - intolerance against milk protein - pregnancy, lactation - chronic bowel diseases |
Salir
Medidas de resultado primarias
1. cholesterol metabolism (blood lipids) [after 1, 5, 10 and 15 weeks]
Medidas de resultado secundarias
1. general excretion parameters, neutral sterols, bile acids, short-chain fatty acids, fibre excretion, cytotoxicity, genotoxicity [after 1, 5, 10 and 15 weeks]
