Nabilone in Cannabis Users With PTSD
Palabras clave
Abstracto
Descripción
This study will compare the effects of smoked cannabis and nabilone on attentional bias toward trauma- related stimuli, subjective and emotional processing to a range of trauma-and non-trauma-related images and physiological reactivity to these stimuli in individuals with CUD and PTSD. Importantly, this study will also probe the abuse related potential of nabilone compared to smoked cannabis in this population, a critical aspect in determining the potential feasibility for its use clinically to treat CUD in PTSD populations. The effects of nabilone will be compared to propranolol as a positive control.
fechas
Verificado por última vez: | 10/31/2019 |
Primero enviado: | 08/13/2017 |
Inscripción estimada enviada: | 08/13/2017 |
Publicado por primera vez: | 08/15/2017 |
Última actualización enviada: | 11/05/2019 |
Última actualización publicada: | 11/07/2019 |
Fecha de inicio real del estudio: | 09/30/2015 |
Fecha estimada de finalización primaria: | 05/31/2019 |
Fecha estimada de finalización del estudio: | 05/31/2019 |
Condición o enfermedad
Intervención / tratamiento
Drug: Nabilone
Drug: Smoked cannabis
Drug: Propranolol
Drug: Placebo
Fase
Grupos de brazos
Brazo | Intervención / tratamiento |
---|---|
Experimental: Nabilone Nabilone capsules (4 mg) | Drug: Nabilone Nabilone capsules (4 mg) |
Active Comparator: Propranolol Propranolol capsules (40mg) | Drug: Propranolol Propranolol capsules (40mg) |
Experimental: Smoked cannabis (0.0 and 5.6% THC) | Drug: Smoked cannabis Cigarettes (0.0 and 5.6% THC) |
Placebo Comparator: Placebo Placebo capsules | Drug: Placebo Placebo capsules |
Criterio de elegibilidad
Edades elegibles para estudiar | 21 Years A 21 Years |
Sexos elegibles para estudiar | All |
Acepta voluntarios saludables | si |
Criterios | Inclusion Criteria: - Current cannabis use - PTSD symptoms - Able to give informed consent and comply with study procedures - Women who are normally cycling and practicing an effective form of birth control other than hormonal contraceptives Exclusion Criteria: - Meeting criteria for certain current psychiatric disorders - Clinical laboratory tests outside of normal limits - History of clinically significant cardiac or respiratory diagnoses - Current parole or probation - Women who are currently pregnant or breastfeeding |
Salir
Medidas de resultado primarias
1. Cue Reactivity [1 month]