The Effect of Daily Mango Intake on Cardiovascular Health

Inclusion Criteria:

- Postmenopausal female: 50-70 years

- Women: lack of menses for at least one year and FSH 23-116.3 mlU/mL

- Subject is willing and able to comply with the study protocols.

- Subject is willing participate in all study procedures

- BMI 25.0 - 40 kg/m2

- Weight ≥ 110 pounds

Exclusion Criteria:

- BMI ≥ 40 kg/m2

- Dislike or allergy for mango

- Self-reported use of daily anticoagulation agents including aspirin, NSAIDs

- Vegan, Vegetarians, food faddists or those consuming a non-traditional diet

- Alcohol consumption > 3 drinks/week (i.e. 1 bottle of beer, ½ glass of wine, and 1 shot of hard liquor)

- Fruit consumption ≥ 2 cups/day

- Vegetable consumption ≥ 3 cups/day for females

- Fatty Fish ≥ 3 times/week

- Coffee/tea ≥ 3 cups/day

- Dark chocolate ≥ 3 oz/day

- Self-reported restriction of physical activity due to a chronic health condition

- Self-reported chronic/routine high intensity exercise

- Self-reported diabetes

- Blood pressure ≥ 140/90 mm Hg

- Self-reported renal or liver disease

- Self-reported heart disease, which includes cardiovascular events and Stroke

- Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT

- Abnormal Liver, CBC or Chemistry panels (laboratory values outside the reference range) if determined to be clinically significant by the study physician.

- Self-reported cancer within past 5 years

- Self-reported malabsorption

- Currently taking prescription drugs or supplements, other than thyroid medication.

- Use of multi-vitamin and mineral other than a general formula of vitamins and minerals that meet the RDA

- Not willing to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.

- Indications of substance or alcohol abuse within the last 3 years

- Screening LDL ≥ 190 mg/dl for those who have 0-1 major risk factors apart from LDL cholesterol (i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL].

- Screening LDL ≥ 160 mg/dl for those who have 2 major risk factors apart from LDL cholesterol [i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL].

(using NCEP calculator http://cvdrisk.nhlbi.nih.gov/calculator.asp);

- Screening LDL ≥ 130 mg/dl for those who have 2 major risk factors apart from LDL cholesterol [i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL], and a Framingham 10-year Risk Score 10-20% (using NCEP calculator http://cvdrisk.nhlbi.nih.gov/calculator.asp).

- Current enrollee in a clinical research study.