False-Negative and False-Positive Results in FDG-PET and PET/CT in Breast Cancer.

PET and PET/CT has been used for the management of breast cancer for initial staging, monitor the treatment response, detect recurrences, and predict tumor behavior. It has found to be useful in detecting primary breast cancer in patients with large primary tumors. However, it has not been used routinely for early diagnosis of primary breast cancer due to certain limitations. In this article, the authors discuss various important factors that can lead to false-negative and false-positive results in PET and PET/computed tomography imaging used for the diagnosis of primary breast cancer.