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TECHNICAL FIELD
The present invention relates to therapeutic formulations and methods for treating liver cancer including safranal and sorafenib.
BACKGROUND
Despite all efforts, more people are diagnosed with hepatocellular carcinoma (HCC); the most common type of primary liver cancer and the second
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BACKGROUND OF THE INVENTION
The enhancement of physical appearance occupies greater focus in human life than nearly all other daily life-related actions. There are far more consumer products available for the beautification of human body than for the treatment of human ailments. The improvement of
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This invention is directed to imidazolyl-cyclic acetals, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of TNF.
Tumour necrosis factor (TNF) is an important
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BACKGROUND OF THE INVENTION
1. The Field of the Invention
The present invention relates to human telomerase, a ribonucleoprotein enzyme involved in human telomere DNA synthesis, and to compounds that inhibit telomerase activity. The invention provides methods, compounds and compositions relating to
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a method for the synthesis of gem-difluorinated C-glycoside compounds derived from podophyllotoxin. It more particularly, but not exclusively, applies to the preparation of compounds which may be notably used in oncology
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BACKGROUND OF THE INVENTION
Cell proliferation requires the transfer of mevalonate pathway intermediates to a group of proteins, small G-proteins and the nuclear lamins among others. Agents targeted to the inhibition of the transfer process (farnesylation, geranylgeranylation), e.g., farnesyl
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FIELD OF THE INVENTION
The present invention relates to processes for the preparation of macrocyclic molecules containing anti-succinate residues which inhibit metalloproteinases such as aggrecanase, and the production of tumor necrosis factor (TNF). The anti-succinates are formed by an Ireland
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FIELD OF THE INVENTION
The present invention relates to processes for the preparation of macrocyclic molecules containing anti-succinate residues which inhibit metalloproteinases such as aggrecanase, and the production of tumor necrosis factor (TNF). The anti-succinates are formed by an Ireland
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BACKGROUND OF THE INVENTION
The present invention relates to a method for preparing novel transcription factors which modify the procedure of transcription of gene information in a messenger RNA and their use.
The leading cause of death in developed countries other than Japan is ischemic heart
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TECHNICAL FIELD
The present invention relates to the treatment of gastrointestinal disease, and/or cancer, and a method of weight gain, via the ingestion of polymeric compositions in humans, animals or birds in need of said treatment.
BACKGROUND ART
Under the conditions of intensive pig-rearing,
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BACKGROUND
Malaria is one of the world's most widespread infectious diseases. Ridley et al., 2002. Much effort is currently being devoted to develop effective vaccines to prevent humans from becoming infected with malaria parasites. LeBlanc et al., 2008; Troye-Blomberg et al., 2007. Treatment of
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BACKGROUND OF THE INVENTION
Throughout this application, various references are referred to within parentheses. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention
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This invention relates to derivatives of indole-3-acetic acid (IAA) and their use as pharmaceuticals, in particular for treating neoplastic disease.
Indole-3-acetic acid: ##STR2##
is a naturally-occurring plant growth phytohormone which has been extensively studied. As long ago as 1956, its effects
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FIELD OF THE INVENTION
The present invention relates to a novel synthesis of octreotide by solid phase synthesis and conjugated peptides using bifunctional chelating agents. In particular, the present invention relates to linkage, cyclization, and radioactive isotope labelling such as by In-111 or
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FIELD OF INVENTION
This invention relates to the isolation, identification, derivatization, and use of natural products. More particularly this invention is directed to substantially pure forms of cytotoxic Annonaceous acetogenins and certain ester and cyclized ether acetogenin
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