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anemia/phosphatase
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Therapy for Chronic Cold Agglutinin Disease
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1. Background
Chronic cold agglutinin disease (CAD) is mediated by monoclonal cold-reactive autoantibodies that bind to erythrocyte surface antigens, causing haemagglutination and complement-mediated haemolysis. Anaemia is severe (Hb 8.0 g/dL or lower) in one-third of patients and complement-induced
Nutritional Education and the Prevention of Iron Depletion in Children 9 Months to 2 Years
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We plan to undertake a randomized controlled trial to evaluate the effectiveness of an office-based educational intervention for the prevention of iron depletion in young children. Healthy children will be recruited from a community pediatric office which serves a diverse, urban population. Children
Cholecalciferol Supplementation Effect on Parathyroid Hormone in Hemodialysis Patients
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Introduction. Vitamin D regulates mineral metabolism. Its deficiency has been associated with diabetes, cancer and increased mortality. 25OH vitamin D (25VD) is stable and suitable for the evaluation of vitamin D sufficiency.
The aim of the study is to evaluate whether cholecalciferol
Intravenous Ferric Carboxymaltose (Ferinject®) With or Without Erythropoietin in Patients Undergoing Orthopaedic Surgery
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TREATMENT:
Patients will be randomised 1:1:1 to one of the following groups:
Group I - Ferinject ® and EPO treatment group 25 patients will be randomised to the Ferinject and EPO treatment group.
For each patient, the cumulative total iron requirement will be calculated using the formula of Ganzoni
Comparison Among Erythropoietin Stimulating Agents
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- Objectives of the study
1. Primary Objective To evaluate efficacy of continuous erythropoietin receptor activator (C.E.R.A.) and Darbepoetin Alfa, to maintain Hemoglobin level - within the target recommended range - among ESRD patients, in direct comparison to currently available ESA (Epoetin alfa
Safety and Efficacy of Iron Reduction by Phlebotomy
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Background Hematopoietic stem cell transplantation (HSCT) is increasingly used as a treatment for a variety of malignant and non-malignant conditions. With improvements in conditioning regimens and post-transplant care, more HSCT recipients are becoming long-term survivors and therefore increasing
Malaria Surveillance in Rakai, Uganda
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Malaria is a leading cause of morbidity and mortality in Uganda, accounting for 25-40 percent of all outpatient visits at health facilities, 20 percent of hospital admissions, and 9-14 percent of inpatient deaths. Malaria is meso- to holoendemic in Rakai, southwestern Uganda and children under 10
Study of the Pathophysiological Mechanisms Involved in Bleeding Events
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Introduction: Lowe syndrome (LS), also known as oculocerebrorenal syndrome of Lowe (OCRL), is a rare X-linked condition characterized by congenital cataracts, defective renal tubule cell function, muscular hypotonia and variable degrees of mental retardation. Patients with LS require frequent
A Trial of Doxil and Multiday Vinorelbine in Patients With Metastatic Breast Cancer
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PROTOCOL SUMMARY
Study design: Phase II trial of monthly Doxil® and vinorelbine on day 1 and 2 in women with metastatic breast cancer.
Treatment plan: Patients will continue therapy, until they have unacceptable toxicity or disease progression.
Primary endpoint: Response rate
Secondary endpoints:
Denosumab Versus Zoledronic Acid in Thalassemia-Induced Osteoporosis
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Despite the significant improvements in the therapeutic management of beta thalassemia major (BTM) over the past few decades, osteoporosis is still a common finding, even in optimally treated patients. The relationships between bone mineral densities (BMD) and several clinical characteristics or
Cardiovascular Profiles in Rheumatoid Arthritis
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Patient Selection:
Screen ~400 Rheumatoid Arthritis (RA) patients followed in Centro Hospitalar do Porto outpatient clinic. All RA patients with regular follow-up will be potentially included.
The investigators also aim to enrol age-matched controls for biomarker comparison.
Experimental
Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI
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Aim of the Study At present, due to the global therapeutic approach, the prognosis of Thalassemia Major and Severe Thalassemia Intermedia is open-ended. Regular transfusional regimens from childhood and early iron chelation therapy prevent bone deformities that in the past characterized this disease
Role of Geminin and Mcm-2 in Prognosis of Renal Cell Carcinoma
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Renal cell carcinoma (RCC) is one of the most common urological malignancies. Approximately 338,000 people are diagnosed with RCC worldwide each year, representing approximately 2-3 % of all cancers.
RCC can be classified into non-epithelial and epithelial, according to cell origin. The four major
Drug-drug Interaction Study With Metformin and Imatinib
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Screening Procedures:
Prior to enrollment, subjects will be asked to come to the Clinical and Translational Science (CTSI) Clinical Research Centre (CRC) at San Francisco General Hospital (SFGH). The study protocol and procedures will be explained in detail, all questions will be answered, and
Drug-Drug Interaction Study With Metformin and Nizatidine
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Screening Procedures:
Prior to enrollment, subjects will be asked to come to the Clinical and Translational Science (CTSI) Clinical Research Centre (CRC) at San Francisco General Hospital (SFGH). The study protocol and procedures will be explained in detail, all questions will be answered, and
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