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Antidepressant reversal of interferon-alpha-induced anhedonia.
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Interferon-alpha(IFN-alpha) is used clinically in the treatment of several pathologies such as hepatitis C and various cancers. The positive therapeutic potential is however often limited by negative secondary effects which include major depression, one of the cardinal symptoms of which is anhedonia
Pegylated human interferon alpha 2a does not induce depression-associated changes in mice.
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Interferon (IFN) alpha proteins are proinflammatory cytokines having immunomodulating and antiviral properties. States during which cytokine systems are activated (e.g., during viral infection or during treatment of chronic hepatitis C and various malignancies with IFN alpha, etc.) can be associated
Effect of psychiatric symptoms and quality of life on cognitive performance in HCV patients.
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OBJECTIVE
Reduced performance in several cognitive domains has been repeatedly related to Hepatitis C Virus (HCV). Nevertheless, there is no consensus about the severity or cognitive profile. Moreover, other possible influential variables are scarcely controlled. The aim of this study is to define
[Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression].
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The use of interferon (IFN)-alpha for the treatment of viral diseases or cancers is associated with neuropsychiatric side effects in a large number of patients. The mechanisms by which cytokines induce these symptoms, as well as the vulnerability factors for these effects, have not been yet fully
Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration.
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BACKGROUND
Inflammatory cytokines or cytokine inducers can alter basal ganglia activity, including reducing responsiveness to rewarding stimuli that may be mediated by cytokine effects on dopamine function.
OBJECTIVE
To determine whether long-term administration of the inflammatory cytokine
Neuropsychiatric disorders related to interferon and interleukins treatment.
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Certain cytokines such as interferon-alpha and interleukin-2 are often used in the treatment certain cancers and chronic diseases such as melanoma, hepatitis C infection and multiple sclerosis. Several neuropsychiatric side effects such as depression, anxiety, psychosis, suicidal ideation, hypomanic
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