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Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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BACKGROUND OF THE INVENTION
The invention relates to new taxanes possessing strong antitumor activities, precursors of these compounds, compositions including these compounds, and processes for synthesizing these compounds and methods for treating tumors by using these new compounds.
Taxol is
Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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BACKGROUND OF THE INVENTION
The invention relates to new taxanes possessing strong antitumor activities, precursors of these compounds, compositions including these compounds, and processes for synthesizing these compounds and methods for treating tumors by using these new compounds.
Taxol is
Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
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BACKGROUND OF THE INVENTION
This work was in part supported by a grant from the National Institute of Health (GM42798).
The invention relates to new taxanes possessing strong antitumor activities, precursors of these compounds, compositions including these compounds, and processes for synthesizing
Methods for preparing new taxoids and pharmaceutical compositions containing them
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The present invention relates to methods of preparing new taxoids of general formula: ##STR2##
in which: Z represents a hydrogen atom or a radical of general formula: ##STR3##
in which: R.sub.1 represents a benzoyl radical optionally substituted with one or more identical or different atoms or
Carboxylic acids for synthesis of taxane derivatives
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DESCRIPTION OF THE INVENTION
The present invention relates to a process for the preparation of taxane derivatives of general formula: ##STR2##
which are particularly advantageous intermediates for preparing taxol, Taxotere and their analogues which have notable antileukaemic and antitumour
Process to prepare taxol
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is a chemical process to prepare taxol and taxol analogs by use of an arylsulfonyloxazolidine.
2. Description of the Related Art
Taxol and taxotere are known to be useful for treating cancer. Numerous documents disclose
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