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[The mechanism of apoptosis of chronic myeloid leukemia cells induced by the novel p210 bcr/abl inhibitor berbamine].
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OBJECTIVE
To investigate the mechanism of apoptosis of chronic myeloid leukemia (CML) cells induced by the novel p210 bcr/abl inhibitor berbamine.
METHODS
Human Ph+ CML leukemia K562 cells, which express endogenous p210 bcr/abl protein, were cultured in RPMI 1640 and treated with berbamine as
[Study on effect of berbamine on multidrug resistance leukemia K562/Adr cells].
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OBJECTIVE
To study the effect and mechanism of berbamine on the apoptosis of multidrug resistant leukemia K562/Adr cells and in reversing the drug resistance.
METHODS
IC50 value of K562/Adr cell was determined with MTT method, cell apoptosis rate was analyzed by flow cytometry with Annexin V FITC-PI
Novel synthetic tosyl chloride-berbamine regresses lethal MYC-positive leukemia by targeting CaMKIIγ/Myc axis.
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Proto-oncogene Myc, a key transcription factor, is frequently deregulated in human leukemia with aggressive and poor clinical outcome, but the development of MYC inhibitors remains challenging due to MYC helix-loop-helix topology lacking druggable domains. Here we describe a novel oral active small
[Effects of berbamine on growth of leukemia cell line NB4 and its mechanism].
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OBJECTIVE
To determine effects of berbamine on the growth of leukemia cell line NB4 and explore its possible mechanisms.
METHODS
The growth of NB4 cells was examined with MTT assay. Morphological analysis and DNA agarose electrophoresis were used to detect apoptosis in NB4 cells, and the apoptosis
Berbamine selectively induces apoptosis of human acute promyelocytic leukemia cells via survivin-mediated pathway.
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BACKGROUND
Currently, resistance and relapse are still major problems in acute promyelocytic leukemia (APL) cases. Thus, new agents that override the resistance are crucial to the development of curative therapies for APL. In this study, we investigated the effects of berbamine on the proliferation
[Mechanism related to inhibition of leukemia K562 cells by berbamine].
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OBJECTIVE
To investigate the mechanism related to the inhibition of leukemia K562 cells by berbamine.
METHODS
After K562 cells were treated with 8 microg/ml berbamine, the expression levels of NF-kappaB, IkappaBalpha, pIkappaBalpha, IKKalpha, A20 were determined by Western blot.
RESULTS
With the
Berbamine overcomes imatinib-induced neutropenia and permits cytogenetic responses in Chinese patients with chronic-phase chronic myeloid leukemia.
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During imatinib therapy, many patients with chronic myeloid leukemia (CML) develop severe neutropenia, leading to treatment interruptions, and potentially compromising response to imatinib. Berbamine (a bisbenzylisoquinoline alkaloid) has been widely used in Asian countries for managing leukopenia
Berbamine: a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity.
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Gleevec, which is an inhibitor of the bcr/abl tyrosine kinase, has been a remarkable success for the treatment of chronic myelogenous leukemia (CML). However, a significant proportion of patients chronically treated with Gleevec develop resistance. Here we describe the activity of a natural small
Berbamine derivatives: a novel class of compounds for anti-leukemia activity.
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Our previous studies showed that the natural compound berbamine, from Chinese herb Berberis amurensis, selectively induces apoptosis of imatinib (IM)-resistant-Bcr/Abl-expressing leukemia cells from the K562 cell line and CML patients. Here, a series of new berbamine derivatives were obtained by
[Detection of P-170 and treatment with berbamine in primary acute leukemia].
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Emerging role of berbamine as an anti-cancer agent in systemic malignancies besides chronic myeloid leukemia.
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Berbamine inhibits proliferation and induces apoptosis of KU812 cells by increasing Smad3 activity.
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OBJECTIVE
The cytotoxic effect of berbamine on chronic myeloid leukemia (CML) cell line KU812 was evaluated, and the mechanisms of its action were explored.
METHODS
The effect of berbamine on the KU812 cell growth was determined by methyl thiazolyl tetrazolium (MTT) assay. Flow cytometry was used to
Inhibition of telomerase activity and bcl-2 expression in berbamine-induced apoptosis in HL-60 cells.
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The present study was aimed to investigate the effect of telomerase activity in berbamine-induced apoptosis and the regulation of B cell leukemia/lymphoma 2 ( bcl-2) gene expression in human leukemia HL-60 cells. Apoptosis of HL-60 cells was induced by berbamine (10 microM) for 3, 6, 12 and 24 h.
Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice.
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Berbamine, a natural compound from the plant Berberis amurensis, is a traditional Chinese medicine mainly used in stimulating normal hematopoiesis in clinic. Our previous studies demonstrated that berbamine has anti-leukemia activity. In this study, we investigated the anticancer activity of
Berbamine exhibits potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo.
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OBJECTIVE
The aim of this study was to explore the effects and mechanism of berbamine on imatinib-resistant BCR-ABL-positive human leukemia K562 (K562-r) cells in vitro and in vivo.
METHODS
Cell viability was measured by MTT assay, and apoptotic morphology changes were detected by fluorescence
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