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The development of radiolabeled amino acids for use as metabolic tracers to image tumors using positron emission tomography (PET) and single photon emission computed tomography (SPECT) has been underway for two decades. Although radiolabeled amino acids have been applied to a variety of tumor types,
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The development of radiolabeled amino acids for use as metabolic tracers to image tumors using positron emission tomography (PET) and single photon emission computed tomography (SPECT) has been underway for two decades. Although radiolabeled amino acids have been applied to a variety of tumor types,
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a national stage filing under section 371 of International Application No. PCT/EP2016/053172, filed on Feb. 15, 2016, and published on Aug. 25, 2016 as WO 2016/131776, which claims priority to Great Britain Application No. 1502567.9, filed
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FIELD OF THE INVENTION
The invention includes novel chemical compounds having specific binding in a biological system and capable of being used for positron emission tomography (PET) and single photon emission (SPECT) imaging methods.
BACKGROUND OF THE INVENTION
The ability of analog compounds to
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FIELD OF THE INVENTION
The invention includes novel chemical compounds having specific binding in a biological system and capable of being used for positron emission tomography (PET) and single photon emission (SPECT) imaging methods.
BACKGROUND OF THE INVENTION
The ability of analog compounds to
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BACKGROUND OF THE DISCLOSURE
This invention relates to a method of treating meningeal leukemia and CNS lymphoma and neoplasms in the brain in man and pharmaceutical preparations suitable for such use.
More effective antileukemic therapy and consequent longer survival has the unfortunate consort of
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This application is a National Stage application of PCT/FR2005/000084, filed Jan. 14, 2005, which claims priority from French patent application FR 0400298, filed Jan. 14, 2004. The entire contents of each of the aforementioned applications are incorporated herein by reference.
The subject of the
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The present invention relates to the use of substituted acryloyl distamycin derivatives, in particular to the use of .alpha.-bromo- and .alpha.-chloroacryloyl distamycin derivatives, in the treatment of tumors associated with high levels of glutathione and/or glutathione-S-transferases family.
More
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BACKGROUND OF THE INVENTION
The present invention relates to DC-89 derivatives. The compounds have an excellent anti-tumor activity and are useful as anti-tumor agents.
As compounds structurally similar to the DC-89 derivatives of the present invention, those represented by the following structure
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CROSS-REFERENCE TO RELATED APPLICATION
This application is a National Stage entry of International Application No. PCT/EP01/07064, filed Jun. 20, 2001, the entire specification claims and drawings of which are incorporated herewith by reference.
The present invention relates to the field of cancer
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BACKGROUND OF THE INVENTION
Anthracyline antibiotics including doxorubicin, daunorubicin, and carminomycin are important chemotherapeutic agents in the treatment of a broad spectrum of neoplastic conditions including acute myeloblastic and lymphoblastic leukemias. Doxorubicin (also known as
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BACKGROUND OF THE INVENTION
Anthracyline antibiotics including doxorubicin, daunorubicin, and carminomycin are important chemotherapeutic agents in the treatment of a broad spectrum of neoplastic conditions including acute myeloblastic and lymphoblastic leukemias. Doxorubicin (also known as
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The present invention relates to prodrugs and their use in the treatment of disease, including cancers.
The use of prodrugs represents a clinically very valuable concept in cancer therapy since. particularly where the prodrug is to be converted to an anti-tumour agent under the influence of an
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TECHNICAL FIELD
The present invention relates to an inhibitor of casein kinase 1.delta. and casein kinase 1.epsilon., which comprises, as an active ingredient, an oxazolone derivative, a salt thereof, a solvate thereof, or a hydrate thereof. The present invention relates to a pharmaceutical agent
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BACKGROUND OF THE INVENTION
This invention relates to novel amino acid analogs having specific and selective binding in a biological system, particularly brain and systemic tumors, and capable of being used for positron emission tomography (PET) and single photon emission (SPECT) imaging
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