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cembrane/leucemia

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New marine cembrane-type diterpenoids from the Okinawan soft coral Clavularia koellikeri.

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Seven new marine diterpenoids having a cembrane skeleton were isolated from the Okinawan soft coral Clavularia koellikeri. Their structures were determined based on the results of spectroscopic analysis and chemical conversions. Compound 1 showed cytotoxic activity against human colorectal

[Cembrane diterpenes in olibanum].

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OBJECTIVE To study the constituents in the chloroform extract of olibanum and their antitumor activities. METHODS The compounds were isolated by chromatographic methods and their structures were identified on the basis of spectroscopic methods and X-ray diffraction. The antiproliferative effect of

Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis.

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Eight cembrane-type diterpenoids, namely, (+)-(6R)-6-hydroxyisosarcophytoxide (1), (+)-(6R)-6-acetoxyisosarcophytoxide (2), (+)-17-hydroxyisosarcophytoxide (3), sarcomililatins A-D (4-7), and sarcomililatol (8), were isolated from the soft

Polyoxygenated cembrane diterpenoids from the soft coral Sarcophyton ehrenbergi.

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Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The

Numerosol A-D, new cembranoid diterpenes from the soft coral Sinularia numerosa.

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Four new cembrane-type diterpenes; numerosol A-D (1-4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited

Secondary metabolites from the soft coral Sinularia arborea.

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Two new 13-hydroxycembrane diterpenoids, arbolides A (1) and B (2), along with a known trihydroxysteroid, crassarosterol A (3), were isolated from the soft coral Sinularia arborea. The structures of new cembranes 1 and 2 were elucidated by spectroscopic methods. Steroid 3 was found to exhibit

Cytotoxic biscembranes from the soft coral Sarcophyton glaucum.

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Seven new tetracyclic biscembranes (1-7) have been isolated from the soft coral Sarcophyton glaucum. Four (1-4) may be formed biogenetically by a Diels-Alder reaction of Delta(4(5)) and Delta(8(9)) geometrical isomers of methyl sarcoate and Delta(21(34), 35(36)) dienes, including two with a

Aquaculture Soft Coral Lobophytum crassum as a Producer of Anti-Proliferative Cembranoids.

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Our continuous search for marine bioactive secondary metabolites led to the screening of crude extracts from a variety of aquaculture soft corals. The ethyl acetate (EtOAc) extract of Lobophytum crassum showed a distinctive chemical profile that was different from the wild type. It demonstrated
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