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dauricine/menispermum
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Early Steps of Dauricine Biosynthesis in Cultured Roots of Menispermum dauricum.
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Cultured roots of Menispermum dauricum, a rich source of the bisbenzylisoquinoline alkaloid dauricine (1), were fed with l-[U-(14)C] tyrosine, L-[3-(13)C] tyrosine, and [2-(13)C] tvramine independently, and the incorporation of possible early precursors into 1 was studied. The results demonstrated
Dauricine negatively regulates lipopolysaccharide- or cecal ligation and puncture-induced inflammatory response via NF-κB inactivation.
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Acute lung injury (ALI) is a challenging clinical problem worldwide characterized by severe pulmonary inflammation. Dauricine, extracted from the root of traditional Chinese medicine Menispermum dauricum DC, is employed as anti-inflammatory herbs. In this study, we explored the inhibitory effects of
P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier.
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Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. The aim of the present study was to investigate the role of P‑glycoprotein in the transport of dauricine across the blood‑brain barrier by pre‑treatment with the P‑glycoprotein inhibitor verapamil.
Dauricine combined with clindamycin inhibits severe pneumonia co-infected by influenza virus H5N1 and Streptococcus pneumoniae in vitro and in vivo through NF-κB signaling pathway.
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Dauricine, isolated from Menispermum dauricum, has been widely used for treatment of various diseases, including cardiac ischemia and inflammation-related diseases. However, little is known regarding to the effect of dauricine on severe pneumonia. Therefore, the aim was to investigate the effect of
Inhibitory effects of a bisbenzylisoquinline alkaloid dauricine on HERG potassium channels.
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BACKGROUND
The roots of Menispermum dauricum have been widely used for the treatment of inflammation, allergy and arrhythmia in China for a long time. Dauricine (Dau), a bisbenzylisoquinline alkaloid from Menispermum dauricum, mainly contributes to the anti-arrhythmic effect and has received
[Effect of dauricine on rat and human platelet aggregation and metabolism of arachidonic acid in washed rat platelets].
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Dauricine (Dau), an isoquinoline alkaloid extracted from the roots of Menispermum dauricum D. C. and used as an antiarrhythmic agent in China recently, was shown to inhibit rat platelet aggregation induced by arachidonic acid (AA) and ADP, as well as human platelet aggregation induced by AA, ADP and
Validated liquid chromatography-tandem mass spectrometry method for quantitative determination of dauricine in human plasma and its application to pharmacokinetic study.
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A highly sensitive and selective LC-MS/MS method was developed and validated for the determination of dauricine in human plasma, using protopine as internal standard (IS). The analyte and IS were extracted by liquid-liquid extraction and analyzed by LC-MS/MS. Chromatographic separation was performed
CYP3A-mediated apoptosis of dauricine in cultured human bronchial epithelial cells and in lungs of CD-1 mice.
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Dauricine is the major bioactive component isolated from the root of Menispermum dauricum DC and has shown promising pharmacologic activities with a great potential for clinical use. Recently, we found that intraperitoneal exposure of dauricine produced selective pulmonary injury in mice. A quinone
Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice.
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Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. and has shown promising pharmacological activities with a great potential for clinic use. However, the adverse effects and toxicity of the alkaloid are unfortunately ignored. The objective of the current
The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro.
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Alzheimer's disease (AD), the most common neurodegenerative disease, has no effective treatment. Dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid isolated from the root of Menispermum dauricum DC, reportedly has neuroprotective effects in cerebral ischemia. Here, we investigated the effects
Studies on the alkaloids of menispermaceous plants. CCXIX. Dauricine from Menispermum canadense L.
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[STUDIES ON THE ALKALOIDS OF MENISPERMACEOUS PLANTS. 208. ALKALOIDS OF MENISPERMUM DAURICUM DC. (SUPPL. 3). DAURICINE].
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[A new alkaloid of Menispermum dauricum DC--dauriciline].
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A new phenolic dauricine-type alkaloid, named "dauriciline", was isolated from the rhizome of Menispermum dauricum DC. It is a pale yellow powder. Based on spectrometric analysis (UV.FAB-MS and 1HNMR) and chemical reaction the structure of the new alkaloid was elucidated as RR,7,7'-demethyldauricine
[Isolation and identification of alkaloids form Menispermum dauricum growing in Xianning].
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The alkaloids of rhizoma of Menispermum dauricum DC growing in Xianning have been subjected to isolation and identification. The results showed that its two major constituents, which are only next of dauricine in content, are dauricinoline and daurinoline, instead of the commonly found daurisoline
[A new alkaloid from Menispermum dauricum DC--N-desmethyldauricine].
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A new phenolic dauricine-type alkaloid together with the know dauricine were isolated from the rhizoma of Menispermum dauricum DC cultivated in Xianning district, Hubei province. Dauricine was obtained as the major alkaloid and was confirmed by comparison with authentic sample. The new alkaloid is
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