5 resultados
OBJECTIVE
To present outcome data in a prospective study of radiotherapy (RT) with concurrent and adjuvant temozolomide (TMZ) in children with diffuse intrinsic pontine gliomas (DIPGs).
METHODS
Pediatric patients with newly diagnosed DIPGs were prospectively treated with focal RT to a dose of 54 Gy
BACKGROUND
We conducted a phase II study of oral capecitabine rapidly disintegrating tablets given concurrently with radiation therapy (RT) to assess progression-free survival (PFS) in children with newly diagnosed diffuse intrinsic pontine gliomas (DIPG).
METHODS
Children 3-17 years with newly
Diffuse intrinsic pontine glioma (DIPG) is a devastating cancer of childhood and adolescence.METHODS
The study included patients between 3 and 20 years with clinically and radiologically confirmed
DIPG. Primary endpoint was 6-month progression-free
BACKGROUND
The prognosis for children with brain stem glioma remains grim. Based on studies suggesting efficacy of vincristine and oral VP-16, The Pediatric Oncology Group (POG, now part of the Children's Oncology Group) conducted a study using these agents in combination with standard external beam
Introduction: Beyond focal radiation, there is no consensus standard therapy for pediatric high-grade glioma (pHGG) and outcomes remain dismal. We describe the largest molecularly-characterized cohort of children with pHGG treated with a