7 resultados
Among the class of epipodophylloids, certain compounds such as etoposide or teniposide, which are semisynthetic compounds derived from epipodophyllotoxin, obtained from natural lignan, are used in the preparation of medicinal products for treating many forms of cancer. They are currently considered
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to dimeric epipodophyllotoxin glucoside derivatives, to their therapeutic anti-tumor use, and to pharmaceutical dosage forms containing these new agents.
2. Description of the Related Art
Etoposide (VP-16, Ia) and
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to novel nitrogen containing derivatives of epipodophyllotoxin glucoside derivatives, to their therapeutic anti-tumor use, and to pharmaceutical dosage forms containing these new agents.
2. Description of the Related
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention provides phosphorous containing derivatives of epipodophyllotoxin glucoside aldehyde or ketone condensation products which have the ability to inhibit transplanted tumors in experimental animals and to the therapeutic
FIELD OF THE INVENTION
The present invention concerns covalent conjugates of topoisomerase I inhibitors (e.g., camptothecins) and topoisomerase II inhibitors (e.g., amsacrine, ellipticines, anthracycline antibiotics, epipodophyllotoxins).
BACKGROUND OF THE INVENTION
Etoposide is a widely-used
FIELD OF THE INVENTION
The present invention concerns taxoid conjugates, pharmaceutical formulations containing the same, and methods of use thereof as antimitotic and antitumor agents, particularly for the treatment of tumors such as breast cancer and ovarian cancer.
BACKGROUND OF THE INVENTION
The
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to 3'-demethoxy epipodophyllotoxin glucoside derivatives, to their therapeutic anti-tumor use, and to pharmaceutical dosage forms containing these new agents.
2. Description of the Related Art
Etoposide (VP-16, Ia)